[HTML][HTML] The role of the PI3K/AKT signalling pathway in the corneal epithelium: recent updates

K Chen, Y Li, X Zhang, R Ullah, J Tong, Y Shen - Cell death & disease, 2022 - nature.com
Abstract Phosphatidylinositol 3 kinase (PI3K)/AKT (also called protein kinase B, PKB)
signalling regulates various cellular processes, such as apoptosis, cell proliferation, the cell …

[HTML][HTML] Niosomal drug delivery systems for ocular disease—Recent advances and future prospects

S Durak, M Esmaeili Rad, A Alp Yetisgin, H Eda Sutova… - Nanomaterials, 2020 - mdpi.com
The eye is a complex organ consisting of several protective barriers and particular defense
mechanisms. Since this organ is exposed to various infections, genetic disorders, and visual …

Super-cationic carbon quantum dots synthesized from spermidine as an eye drop formulation for topical treatment of bacterial keratitis

HJ Jian, RS Wu, TY Lin, YJ Li, HJ Lin, SG Harroun… - ACS …, 2017 - ACS Publications
We have developed a one-step method to synthesize carbon quantum dots (CQDPAs) from
biogenic polyamines (PAs) as an antibacterial agent for topical treatment of bacterial …

[PDF][PDF] An ocular commensal protects against corneal infection by driving an interleukin-17 response from mucosal γδ T cells

AJS Leger, JV Desai, RA Drummond, A Kugadas… - Immunity, 2017 - cell.com
Mucosal sites such as the intestine, oral cavity, nasopharynx, and vagina all have
associated commensal flora. The surface of the eye is also a mucosal site, but proof of a …

Functional carbon quantum dots for ocular imaging and therapeutic applications

VB Kumar, I Sher, S Rencus‐Lazar, Y Rotenstreich… - Small, 2023 - Wiley Online Library
Carbon quantum dots (CDs) are a class of emerging carbonaceous nanomaterials that have
received considerable attention due to their excellent fluorescent properties, extremely small …

Carbonized nanogels for simultaneous antibacterial and antioxidant treatment of bacterial keratitis

HY Lin, SW Wang, JY Mao, HT Chang… - Chemical Engineering …, 2021 - Elsevier
To prevent visual loss, clinical therapy of severe bacterial keratitis (BK) demands
simultaneous remedying of the damage caused by bacterial infection and its induced …

BCLA CLEAR-Contact lens wettability, cleaning, disinfection and interactions with tears

M Willcox, N Keir, V Maseedupally, S Masoudi… - Contact Lens and …, 2021 - Elsevier
Contact lens materials have undergone significant changes over the past 20 years,
particularly with respect to the introduction of silicone hydrogel materials. Whilst this …

[HTML][HTML] Innate immune system activation, inflammation and corneal wound healing

N Fortingo, S Melnyk, SH Sutton, MA Watsky… - International journal of …, 2022 - mdpi.com
Corneal wounds resulting from injury, surgeries, or other intrusions not only cause pain, but
also can predispose an individual to infection. While some inflammation may be beneficial to …

[HTML][HTML] Next-generation nanomaterials: advancing ocular anti-inflammatory drug therapy

J Wei, J Mu, Y Tang, D Qin, J Duan, A Wu - Journal of nanobiotechnology, 2023 - Springer
Ophthalmic inflammatory diseases, including conjunctivitis, keratitis, uveitis, scleritis, and
related conditions, pose considerable challenges to effective management and treatment …

Ferrous sulfate-loaded hydrogel cures Staphylococcus aureus infection via facilitating a ferroptosis-like bacterial cell death in a mouse keratitis model

Z Wang, H Li, W Zhou, J Lee, Z Liu, Z An, D Xu, H Mo… - Biomaterials, 2022 - Elsevier
Hydrogels loaded with ampicillin, vancomycin or other antibiotics are one of the most widely
used therapeutic agents for keratitis caused by Staphylococcus aureus. However …