Nephrotoxicity is a significant concern during the development of new drugs or when
assessing the safety of chemicals in consumer products. Traditional methods for testing …

Introduction Due to its role in absorption and metabolism, the kidney is an important target
for drug toxicity. Drug-induced nephrotoxicity (DIN) presents a significant challenge in …

The mechanisms underlying colistin-induced toxicity are not fully understood. This study
used untargeted metabolomics and transcriptomics to elucidate the molecular processes …

The aim of this study was to investigate changes in the intracellular metabolism resulting
from cisplatin (CDDP)-induced nephrotoxicity in normal kidney tubular epithelial NRK-52E …

Background Pueraria montana var. lobata (Willd.) Maesen & SM Almeida ex Sanjappa &
Predeep (syn. Pueraria lobata (Willd.) Ohwi) and Schisandra sphenanthera Rehder & EH …

Oral poisoning can trigger diverse physiological reactions, determined by the toxic
substance involved. One such consequence is hyperchloremia, characterized by an …

Platinum-based chemotherapies are essential in the treatment of several malignancies.
However, such medications can damage the kidneys, frequently leading to both acute and …

Acute kidney injury (AKI) is a heterogeneous syndrome, comprising diverse etiologies of
kidney insults that result in high mortality and morbidity if not well managed. Although great …

Omics applications in nephrology may have relevance in the future to improve clinical care
of kidney disease patients. In a short term, patients will benefit from specific measurement …

Angiogenesis inhibitors such as tyrosine kinase inhibitors (TKIs) are common therapeutics
currently used to treat oncologic disease. Surufatinib is a novel, small-molecule multiple …