The physiology, pathology, and pharmacology of voltage-gated calcium channels and their future therapeutic potential

GW Zamponi, J Striessnig, A Koschak… - Pharmacological …, 2015 - Elsevier
Voltage-gated calcium channels are required for many key functions in the body. In this
review, the different subtypes of voltage-gated calcium channels are described and their …

Voltage-gated calcium channels

WA Catterall - Cold Spring Harbor perspectives in …, 2011 - cshperspectives.cshlp.org
Voltage-gated calcium (Ca2+) channels are key transducers of membrane potential
changes into intracellular Ca2+ transients that initiate many physiological events. There are …

Structure and Regulation of Voltage-Gated Ca2+ Channels

WA Catterall - Annual review of cell and developmental biology, 2000 - annualreviews.org
▪ Abstract Voltage-gated Ca2+ channels mediate Ca2+ entry into cells in response to
membrane depolarization. Electrophysiological studies reveal different Ca2+ currents …

[图书][B] Excitation-contraction coupling and cardiac contractile force

D Bers - 2001 - books.google.com
How is the heartbeat generated? What controls the strength of contraction of heart muscle?
What are the links between cardiac structure and function? How does our understanding of …

Molecular physiology of cardiac repolarization

JM Nerbonne, RS Kass - Physiological reviews, 2005 - journals.physiology.org
The heart is a rhythmic electromechanical pump, the functioning of which depends on action
potential generation and propagation, followed by relaxation and a period of refractoriness …

L-Type CaV1.2 Calcium Channels: From In Vitro Findings to In Vivo Function

F Hofmann, V Flockerzi, S Kahl… - Physiological …, 2014 - journals.physiology.org
The L-type Cav1. 2 calcium channel is present throughout the animal kingdom and is
essential for some aspects of CNS function, cardiac and smooth muscle contractility …

Calcium channel auxiliary α2δ and β subunits: trafficking and one step beyond

AC Dolphin - Nature Reviews Neuroscience, 2012 - nature.com
The voltage-gated calcium channel α2δ and β subunits are traditionally considered to be
auxiliary subunits that enhance channel trafficking, increase the expression of functional …

The β Subunit of Voltage-Gated Ca2+ Channels

Z Buraei, J Yang - Physiological reviews, 2010 - journals.physiology.org
Calcium regulates a wide spectrum of physiological processes such as heartbeat, muscle
contraction, neuronal communication, hormone release, cell division, and gene …

Identification and differential subcellular localization of the neuronal class C and class D L-type calcium channel alpha 1 subunits.

JW Hell, RE Westenbroek, C Warner… - The Journal of cell …, 1993 - rupress.org
To identify and localize the protein products of genes encoding distinct L-type calcium
channels in central neurons, anti-peptide antibodies specific for the class C and class D …

Voltage-gated ion channels and gating modifier toxins

WA Catterall, S Cestèle, V Yarov-Yarovoy, HY Frank… - Toxicon, 2007 - Elsevier
Voltage-gated sodium, calcium, and potassium channels generate electrical signals
required for action potential generation and conduction and are the molecular targets for a …