Effects of in vivo conditions on amyloid aggregation
One of the grand challenges of biophysical chemistry is to understand the principles that
govern protein misfolding and aggregation, which is a highly complex process that is …
govern protein misfolding and aggregation, which is a highly complex process that is …
Multi-target-directed ligands and other therapeutic strategies in the search of a real solution for Alzheimer's disease
A Agis-Torres, M Sollhuber… - Current …, 2014 - ingentaconnect.com
The lack of an adequate therapy for Alzheimer's Disease (AD) contributes greatly to the
continuous growing amount of papers and reviews, reflecting the important efforts made by …
continuous growing amount of papers and reviews, reflecting the important efforts made by …
Amyloid blood biomarker detects Alzheimer's disease
Alzheimer's disease (AD) is currently incurable, but there is general agreement that a
minimally invasive blood biomarker for screening in preclinical stages would be crucial for …
minimally invasive blood biomarker for screening in preclinical stages would be crucial for …
Function and toxicity of amyloid beta and recent therapeutic interventions targeting amyloid beta in Alzheimer's disease
K Rajasekhar, M Chakrabarti… - Chemical …, 2015 - pubs.rsc.org
Amyloidogenesis has been implicated in a broad spectrum of diseases in which amyloid
protein is invariably misfolded and deposited in cells and organs. Alzheimer's disease is one …
protein is invariably misfolded and deposited in cells and organs. Alzheimer's disease is one …
Amyloid-β peptide dimers undergo a random coil to β-sheet transition in the aqueous phase but not at the neuronal membrane
Mounting evidence suggests that the neuronal cell membrane is the main site of oligomer-
mediated neuronal toxicity of amyloid-β peptides in Alzheimer's disease. To gain a detailed …
mediated neuronal toxicity of amyloid-β peptides in Alzheimer's disease. To gain a detailed …
β-Amyloid peptides display protective activity against the human Alzheimer's disease-associated herpes simplex virus-1
K Bourgade, H Garneau, G Giroux, AY Le Page… - Biogerontology, 2015 - Springer
Amyloid plaques, the hallmark of Alzheimer's disease (AD), contain fibrillar β-amyloid (Aβ) 1-
40 and 1-42 peptides. Herpes simplex virus 1 (HSV-1) has been implicated as a risk factor …
40 and 1-42 peptides. Herpes simplex virus 1 (HSV-1) has been implicated as a risk factor …
[HTML][HTML] UB-311, a novel UBITh® amyloid β peptide vaccine for mild Alzheimer's disease
Introduction A novel amyloid β (Aβ) synthetic peptide vaccine (UB-311) has been evaluated
in a first-in-human trial with patients of mild-to-moderate Alzheimer's disease. We describe …
in a first-in-human trial with patients of mild-to-moderate Alzheimer's disease. We describe …
Amyloid‐beta misfolding and GFAP predict risk of clinical Alzheimer's disease diagnosis within 17 years
Introduction Blood‐based biomarkers for Alzheimer's disease (AD) are urgently needed.
Here, four plasma biomarkers were measured at baseline in a community‐based cohort …
Here, four plasma biomarkers were measured at baseline in a community‐based cohort …
High-resolution probing of early events in amyloid-β aggregation related to Alzheimer's disease
In Alzheimer's disease (AD), soluble oligomers of amyloid-β (Aβ) are emerging as a crucial
entity in driving disease progression as compared to insoluble amyloid deposits. The lacuna …
entity in driving disease progression as compared to insoluble amyloid deposits. The lacuna …
Protein misfolding and amyloid nucleation through liquid–liquid phase separation
Liquid–liquid phase separation (LLPS) is an emerging phenomenon in cell physiology and
diseases. The weak multivalent interaction prerequisite for LLPS is believed to be facilitated …
diseases. The weak multivalent interaction prerequisite for LLPS is believed to be facilitated …