The hypothalamus is critical to the coordination of energy balance and glucose
homeostasis. It responds to peripheral factors, such as insulin and leptin, that convey to the …

Multiple proven and potential risk factors for the development of rheumatoid arthritis (RA)
have been identified, and represent interactions between genes and the environment …

Immune checkpoint blockade is effective for some patients with cancer, but most are
refractory to current immunotherapies and new approaches are needed to overcome …

Obesity is a major driver of cancer, especially hepatocellular carcinoma (HCC). The
prevailing view is that non-alcoholic steatohepatitis (NASH) and fibrosis or cirrhosis are …

Immunotherapies aimed at alleviating the inhibitory constraints on T cells have
revolutionized cancer management. To date, these have focused on the blockade of cell …

CD8+ T cell exhaustion is a state of dysfunction acquired in chronic viral infection and
cancer, characterized by the formation of Slamf6+ progenitor exhausted and Tim-3+ …

The primary task of white adipose tissue (WAT) is the storage of lipids. However," beige"
adipocytes also exist in WAT. Beige adipocytes burn fat and dissipate the energy as heat …

The inhibition of protein tyrosine phosphatases 1B (PTP1B) and N2 (PTPN2) has emerged
as an exciting approach for bolstering T cell anti-tumor immunity. ABBV-CLS-484 is a …

PTP1B, a validated therapeutic target for diabetes and obesity, has a critical positive role in
HER2 signaling in breast tumorigenesis. Efforts to develop therapeutic inhibitors of PTP1B …

Background & Aims The mechanisms by which macrophages regulate intestinal epithelial
cell (IEC) barrier properties are poorly understood. Protein tyrosine phosphatase non …