Research into the potential benefits of artificial intelligence for comprehending the intricate
biology of cancer has grown as a result of the widespread use of deep learning and …

Tumours are surrounded by a host immune system that can suppress or promote tumour
growth. The tumour microenvironment (TME) has often been framed as a singular entity …

Although patients with microsatellite instable metastatic colorectal cancer (CRC) benefit from
immune checkpoint blockade, chemotherapy with targeted therapies remains the only …

The historical lack of preclinical models reflecting the genetic heterogeneity of multiple
myeloma (MM) hampers the advance of therapeutic discoveries. To circumvent this …

Small cell lung cancer (SCLC) is an aggressive malignancy composed of distinct
transcriptional subtypes, but implementing subtyping in the clinic has remained challenging …

To improve the understanding of chemo-refractory high-grade serous ovarian cancers
(HGSOCs), we characterized the proteogenomic landscape of 242 (refractory and sensitive) …

Checkpoint inhibition immunotherapy has revolutionized cancer treatment, but many
patients show resistance. Here we perform integrative transcriptomic and proteomic …

Cancer immunotherapy is a method of controlling and eliminating tumors by reactivating the
body's cancer-immunity cycle and restoring its antitumor immune response. The increased …

Adding anti–programmed cell death protein 1 (anti–PD-1) to 5-fluorouracil (5-FU)/platinum
improves survival in some advanced gastroesophageal adenocarcinomas (GEA). To …

Purpose: Cancer drug development is currently limited by a paradigm of preclinical
evaluation that does not adequately recapitulate the complexity of the intact human tumor …