Purpose To review and synthesise prognostic indices that predict subsequent risk,
prescriptive indices that moderate treatment response, and mechanisms that underlie each …

We aimed to identify diagnosis-specific/transdiagnostic/transoutcome multivariable
candidate predictors (MCPs) of key outcomes in mental disorders. We conducted an …

For many years, psychiatrists have tried to understand factors involved in response to
medications or psychotherapies, in order to personalize their treatment choices. There is …

Rationale Recent clinical trials are reporting marked improvements in mental health
outcomes with psychedelic drug-assisted psychotherapy. Objectives Here, we report on …

Ketamine has emerged as a transformative and mechanistically novel pharmacotherapy for
depression. Its rapid onset of action, efficacy for treatment-resistant symptoms, and …

In light of the National Institute of Mental Health (NIMH)'s Research Domain Criteria (RDoC),
the advent of functional neuroimaging, novel technologies and methods provide new …

Ketamine is an open channel blocker of ionotropic glutamatergic N-Methyl-D-Aspartate
(NMDA) receptors. The discovery of its rapid antidepressant effects in patients with …

Background Relevant studies have shown that gut microbiome plays an important role in the
occurrence, development and treatment of major depressive disorder (MDD). Many studies …

Background: Most guidelines for major depressive disorder recommend initial treatment with
either a second-generation antidepressant (SGA) or cognitive behavioral therapy (CBT) …

Background Predicting future states of psychopathology such as depressive episodes has
been a hallmark initiative in mental health research. Dynamical systems theory has …