Hepatitis D virus in 2021: virology, immunology and new treatment approaches for a difficult-to-treat disease
S Urban, C Neumann-Haefelin, P Lampertico - Gut, 2021 - gut.bmj.com
Approximately 5% of individuals infected with hepatitis B virus (HBV) are coinfected with
hepatitis D virus (HDV). Chronic HBV/HDV coinfection is associated with an unfavourable …
hepatitis D virus (HDV). Chronic HBV/HDV coinfection is associated with an unfavourable …
[HTML][HTML] New insights into HDV persistence: The role of interferon response and implications for upcoming novel therapies
Chronic hepatitis D (CHD), a global health problem, manifests as the most severe form of
viral hepatitis. The causative agent, hepatitis D virus (HDV), is the smallest known human …
viral hepatitis. The causative agent, hepatitis D virus (HDV), is the smallest known human …
Liver-resident bystander CD8+ T cells contribute to liver disease pathogenesis in chronic hepatitis D virus infection
H Kefalakes, XJ Horgan, MK Jung, G Amanakis… - Gastroenterology, 2021 - Elsevier
Background & Aims The hepatitis D virus (HDV) causes the most severe form of chronic
hepatitis, often progressing to cirrhosis within 5 to 10 years. There is no curative treatment …
hepatitis, often progressing to cirrhosis within 5 to 10 years. There is no curative treatment …
[HTML][HTML] Mutations in hepatitis D virus allow it to escape detection by CD8+ T cells and evolve at the population level
H Karimzadeh, MM Kiraithe, V Oberhardt, ES Alizei… - Gastroenterology, 2019 - Elsevier
Background & Aims Hepatitis D virus (HDV) superinfection in patients with hepatitis B virus
(HBV) is associated with rapid progression to liver cirrhosis and hepatocellular carcinoma …
(HBV) is associated with rapid progression to liver cirrhosis and hepatocellular carcinoma …
[HTML][HTML] Hepatitis B and Hepatitis D Viruses: A Comprehensive update with an immunological focus
DG Sausen, O Shechter, W Bietsch, Z Shi… - International Journal of …, 2022 - mdpi.com
Hepatitis B virus (HBV) and hepatitis delta virus (HDV) are highly prevalent viruses
estimated to infect approximately 300 million people and 12–72 million people worldwide …
estimated to infect approximately 300 million people and 12–72 million people worldwide …
Hepatitis D virus-specific CD8+ T cells have a memory-like phenotype associated with viral immune escape in patients with chronic hepatitis D virus infection
Background & Aim Hepatitis D virus (HDV) superinfection of patients with chronic HBV
infection results in rapid progression to liver cirrhosis. Little is known about HDV-specific T …
infection results in rapid progression to liver cirrhosis. Little is known about HDV-specific T …
[HTML][HTML] Innate immunity in hepatitis B and D virus infection: consequences for viral persistence, inflammation, and T cell recognition
M Dandri, A Bertoletti, M Lütgehetmann - Seminars in Immunopathology, 2021 - Springer
Chronic infections with human hepatitis viruses continue to be a major health burden
worldwide. Despite the availability of an effective prophylactic vaccine against the hepatitis B …
worldwide. Despite the availability of an effective prophylactic vaccine against the hepatitis B …
[HTML][HTML] HDV pathogenesis: unravelling ariadne's thread
ED Tseligka, S Clément, F Negro - Viruses, 2021 - mdpi.com
Hepatitis Delta virus (HDV) lies in between satellite viruses and viroids, as its unique
molecular characteristics and life cycle cannot categorize it according to the standard …
molecular characteristics and life cycle cannot categorize it according to the standard …
[HTML][HTML] Adaptive immune responses, immune escape and immune-mediated pathogenesis during HDV infection
V Oberhardt, M Hofmann, R Thimme… - Viruses, 2022 - mdpi.com
The hepatitis delta virus (HDV) is the smallest known human virus, yet it causes great harm
to patients co-infected with hepatitis B virus (HBV). As a satellite virus of HBV, HDV requires …
to patients co-infected with hepatitis B virus (HBV). As a satellite virus of HBV, HDV requires …
[HTML][HTML] Mutational escape from cellular immunity in viral hepatitis: variations on a theme
ES Alizei, M Hofmann, R Thimme… - Current Opinion in …, 2021 - Elsevier
Approx. 320 million individuals worldwide are chronically infected with hepatitis viruses,
contributing to viral hepatitis being one of the 10 leading causes of death. Cellular adaptive …
contributing to viral hepatitis being one of the 10 leading causes of death. Cellular adaptive …