Mannich bases in medicinal chemistry and drug design
G Roman - European journal of medicinal chemistry, 2015 - Elsevier
The biological activity of Mannich bases, a structurally heterogeneous class of chemical
compounds that are generated from various substrates through the introduction of an …
compounds that are generated from various substrates through the introduction of an …
A not-so-ancient grease history: click chemistry and protein lipid modifications
Protein lipid modification involves the attachment of hydrophobic groups to proteins via
ester, thioester, amide, or thioether linkages. In this review, the specific click chemical …
ester, thioester, amide, or thioether linkages. In this review, the specific click chemical …
Structure and Functional Diversity of GCN5-Related N-Acetyltransferases (GNAT)
AIM Salah Ud-Din, A Tikhomirova… - International journal of …, 2016 - mdpi.com
General control non-repressible 5 (GCN5)-related N-acetyltransferases (GNAT) catalyze the
transfer of an acyl moiety from acyl coenzyme A (acyl-CoA) to a diverse group of substrates …
transfer of an acyl moiety from acyl coenzyme A (acyl-CoA) to a diverse group of substrates …
Metabolic reprogramming of ovarian cancer involves ACSL1-mediated metastasis stimulation through upregulated protein myristoylation
As a result of the hostile microenvironment, metabolic alterations are required to enable the
malignant growth of cancer cells. To understand metabolic reprogramming during …
malignant growth of cancer cells. To understand metabolic reprogramming during …
High-resolution snapshots of human N-myristoyltransferase in action illuminate a mechanism promoting N-terminal Lys and Gly myristoylation
C Dian, I Pérez-Dorado, F Rivière, T Asensio… - Nature …, 2020 - nature.com
The promising drug target N-myristoyltransferase (NMT) catalyses an essential protein
modification thought to occur exclusively at N-terminal glycines (Gly). Here, we present high …
modification thought to occur exclusively at N-terminal glycines (Gly). Here, we present high …
Myristoylation confers noncanonical AMPK functions in autophagy selectivity and mitochondrial surveillance
AMP-activated protein kinase (AMPK) plays a central role in cellular energy sensing and
bioenergetics. However, the role of AMPK in surveillance of mitochondrial damage and …
bioenergetics. However, the role of AMPK in surveillance of mitochondrial damage and …
Targeting N-myristoylation for therapy of B-cell lymphomas
E Beauchamp, MC Yap, A Iyer… - Nature …, 2020 - nature.com
Myristoylation, the N-terminal modification of proteins with the fatty acid myristate, is critical
for membrane targeting and cell signaling. Because cancer cells often have increased N …
for membrane targeting and cell signaling. Because cancer cells often have increased N …
Recent approaches to chemical discovery and development against malaria and the neglected tropical diseases human African trypanosomiasis and schistosomiasis
Neglected tropical diseases (NTDs) refer to a group of infectious diseases, which though
treatable and/or preventable, remain a leading cause of morbidity and mortality among the …
treatable and/or preventable, remain a leading cause of morbidity and mortality among the …
Design, synthesis, bio-evaluation, and in silico studies of some N-substituted 6-(chloro/nitro)-1 H-benzimidazole derivatives as antimicrobial and anticancer agents
A new series of 6-substituted 1H-benzimidazole derivatives were synthesized by reacting
various substituted aromatic aldehydes with 4-nitro-o-phenylenediamine and 4-chloro-o …
various substituted aromatic aldehydes with 4-nitro-o-phenylenediamine and 4-chloro-o …
Nuclear functions of the tyrosine kinase Src
G Bagnato, M Leopizzi, E Urciuoli… - International Journal of …, 2020 - mdpi.com
Src is the representative member of the Src-family kinases (SFKs), a group of tyrosine
kinases involved in several cellular processes. Its main function has been for long confined …
kinases involved in several cellular processes. Its main function has been for long confined …