One of the most significant health problems in the American continent in terms of human
health, and socioeconomic impact is Chagas disease, caused by the protozoan parasite …

In this" Critical Review" we made a historical introduction of drugs assayed against Chagas
disease beginning in 1912 with the works of Mayer and Rocha Lima up to the experimental …

Trypanosomatids differ from. ail other organisms in their abirity to conJugare the-sulfur-
containing tripeptide, glutathio-ne, and the poryaminJ, spermioine, to form trypanothione …

Leishmaniasis is a neglected tropical disease that affects about 350 million individuals
worldwide. The protozoan parasite has a relatively simple life cycle with two principal …

Human African trypanosomiasis (HAT), also known as sleeping sickness, is a major cause of
mortality and morbidity in sub-Saharan Africa. Current therapy with melarsoprol for CNS …

The protozoan parasites Trypanosoma brucei and Trypanosoma cruzi are the causative
agents of African trypanosomiasis and Chagas disease, respectively. These are debilitating …

Trypanothione reductase (TR) is both a valid and an attractive target for the design of new
trypanocidal drugs. Starting from menadione, plumbagin, and juglone, three distinct series of …

Naphthoquinones are compounds present in several families of higher plants. Their
molecular structures confer redox properties, and they are involved in multiple biological …

Parasitic diseases such as sleeping sickness, Chagas' heart disease, and malaria are major
health problems in poverty‐stricken areas. Antiparasitic drugs that are not only active but …

Over the last few years a remarkable progress has been made in the understanding of
parasites biochemistry, molecular biology, and immunology. This progress is especially …