[HTML][HTML] How drugs get into cells: tested and testable predictions to help discriminate between transporter-mediated uptake and lipoidal bilayer diffusion
One approach to experimental science involves creating hypotheses, then testing them by
varying one or more independent variables, and assessing the effects of this variation on the …
varying one or more independent variables, and assessing the effects of this variation on the …
Optimized approaches for quantification of drug transporters in tissues and cells by MRM proteomics
B Prasad, JD Unadkat - The AAPS journal, 2014 - Springer
Drug transporter expression in tissues (in vivo) usually differs from that in cell lines used to
measure transporter activity (in vitro). Therefore, quantification of transporter expression in …
measure transporter activity (in vitro). Therefore, quantification of transporter expression in …
Liquid biopsy enables quantification of the abundance and interindividual variability of hepatic enzymes and transporters
B Achour, ZM Al‐Majdoub… - Clinical …, 2021 - Wiley Online Library
Variability in individual capacity for hepatic elimination of therapeutic drugs is well
recognized and is associated with variable expression and activity of liver enzymes and …
recognized and is associated with variable expression and activity of liver enzymes and …
Non-uniformity of changes in drug-metabolizing enzymes and transporters in liver cirrhosis: implications for drug dosage adjustment
Liver cirrhosis is a chronic disease that affects the liver structure, protein expression, and
overall metabolic function. Abundance data for drug-metabolizing enzymes and transporters …
overall metabolic function. Abundance data for drug-metabolizing enzymes and transporters …
Proteomic quantification of human blood–brain barrier SLC and ABC transporters in healthy individuals and dementia patients
ZM Al-Majdoub, H Al Feteisi, B Achour… - Molecular …, 2019 - ACS Publications
The blood–brain barrier (BBB) maintains brain homeostasis by controlling traffic of
molecules from the circulation into the brain. This function is predominantly dependent on …
molecules from the circulation into the brain. This function is predominantly dependent on …
Simultaneous quantification of the abundance of several cytochrome P450 and uridine 5′-diphospho-glucuronosyltransferase enzymes in human liver microsomes …
Cytochrome P450 (P450) and uridine 5′-diphospho-glucuronosyltransferase (UGT)
enzymes mediate a major proportion of phase I and phase II metabolism of xenobiotics. In …
enzymes mediate a major proportion of phase I and phase II metabolism of xenobiotics. In …
Toward a consensus on applying quantitative liquid chromatography‐tandem mass spectrometry proteomics in translational pharmacology research: a white paper
Quantitative translation of information on drug absorption, disposition, receptor engagement,
and drug–drug interactions from bench to bedside requires models informed by …
and drug–drug interactions from bench to bedside requires models informed by …
Quantitative proteomics of clinically relevant drug-metabolizing enzymes and drug transporters and their intercorrelations in the human small intestine
N Couto, ZM Al-Majdoub, S Gibson, PJ Davies… - Drug Metabolism and …, 2020 - ASPET
The levels of drug-metabolizing enzymes (DMEs) and transporter proteins in the human
intestine are pertinent to determine oral drug bioavailability. Despite the paucity of reports on …
intestine are pertinent to determine oral drug bioavailability. Despite the paucity of reports on …
Identification and quantification of blood–brain barrier transporters in isolated rat brain microvessels
H Al Feteisi, ZM Al‐Majdoub, B Achour… - Journal of …, 2018 - Wiley Online Library
The blood–brain barrier (BBB) maintains brain homeostasis by tightly regulating the
exchange of molecules with systemic circulation. It consists primarily of microvascular …
exchange of molecules with systemic circulation. It consists primarily of microvascular …
Absolute protein quantification of clinically relevant cytochrome P450 enzymes and UDP-glucuronosyltransferases by mass spectrometry-based targeted proteomics
C Gröer, D Busch, M Patrzyk, K Beyer… - … of pharmaceutical and …, 2014 - Elsevier
Cytochrome P450 (CYP) enzymes and UDP-glucuronosyltransferases (UGT) are major
determinants in the pharmacokinetics of most drugs on the market. To investigate their …
determinants in the pharmacokinetics of most drugs on the market. To investigate their …