Cytoskeletal dynamics in epithelial-mesenchymal transition: insights into therapeutic targets for cancer metastasis

A Datta, S Deng, V Gopal, KCH Yap, CE Halim, ML Lye… - Cancers, 2021 - mdpi.com
Simple Summary The epithelial to mesenchymal transition (EMT) is a well-documented
process in the study of cancer metastases. The cytoskeleton is an intricate network involved …

Machine learning approaches to predict drug efficacy and toxicity in oncology

BA Badwan, G Liaropoulos, E Kyrodimos, D Skaltsas… - Cell reports …, 2023 - cell.com
In recent years, there has been a surge of interest in using machine learning algorithms
(MLAs) in oncology, particularly for biomedical applications such as drug discovery, drug …

The microtubule destabilizer eribulin synergizes with STING agonists to promote antitumor efficacy in triple-negative breast cancer models

L Takahashi-Ruiz, CS Fermaintt, NJ Wilkinson… - Cancers, 2022 - mdpi.com
Simple Summary Microtubule-targeting agents are a class of chemotherapeutics used to
treat triple-negative breast cancer (TNBC). These include drugs such as eribulin that …

Recent advances in drug discovery for triple-negative breast cancer treatment

D Masci, C Naro, M Puxeddu, A Urbani, C Sette… - Molecules, 2023 - mdpi.com
Triple-negative breast cancer (TNBC) is one of the most heterogeneous and aggressive
breast cancer subtypes with a high risk of death on recurrence. To date, TNBC is very …

Eribulin inhibits growth of cutaneous squamous cell carcinoma cell lines and a novel patient-derived xenograft

CY Hsu, T Yanagi, T Maeda, H Nishihara… - Scientific reports, 2023 - nature.com
Advanced cutaneous squamous cell carcinoma (cSCC) is treated with chemotherapy and/or
radiotherapy, but these typically fail to achieve satisfactory clinical outcomes. There have …

Advances in pyrazole based scaffold as cyclin-dependent kinase 2 inhibitors for the treatment of cancer

J Shaikh, K Patel, T Khan - Mini Reviews in Medicinal …, 2022 - ingentaconnect.com
The transformation of a normal cell into a tumor cell is one of the initial steps in cell cycle
deregulation. The cell cycle is regulated by cyclin-dependent kinases (CDKs) that belong to …

[HTML][HTML] Immunotherapy using PD-1/PDL-1 inhibitors in metastatic triple-negative breast cancer: A systematic review

DF Tavares, VC Ribeiro, MAV Andrade… - Oncology …, 2021 - ncbi.nlm.nih.gov
Breast cancer is the most commonly diagnosed cancer in women and is one of the leading
causes of death from cancer in women worldwide. Despite the significant benefits of using …

[HTML][HTML] Eribulin in breast cancer: Current insights and therapeutic perspectives

O Oey, W Wijaya, A Redfern - World Journal of Experimental …, 2024 - ncbi.nlm.nih.gov
Eribulin is a non-taxane synthetic analogue approved in many countries as third-line
treatment for the treatment of patients with metastatic breast cancer. In addition to its mitotic …

Treatment response to eribulin and anlotinib in lung metastases from rare perianal adenoid cystic carcinoma: a case report

S Zheng, H Li, Y Lin, Y Xie, Z Yin, W Ge, T Yu - Anti-Cancer Drugs, 2022 - journals.lww.com
Adenoid cystic carcinoma (ACC) is a rare salivary glands tumor and often displays
aggressive behavior with frequent relapse and metastasis. The terminal ACC lacks standard …

The temporal mutational and immune tumour microenvironment remodelling of HER2-negative primary breast cancers

L De Mattos-Arruda, J Cortes, J Blanco-Heredia… - NPJ Breast …, 2021 - nature.com
The biology of breast cancer response to neoadjuvant therapy is underrepresented in the
literature and provides a window-of-opportunity to explore the genomic and …