Noroviruses are the major viral pathogens causing epidemic and endemic acute
gastroenteritis with significant morbidity and mortality. While vaccines against norovirus …

Human noroviruses are recognised as the major global cause of viral gastroenteritis. Here,
we provide an overview of notable advances in norovirus research and provide a short …

Human noroviruses (HuNoVs) are the leading cause of epidemic and sporadic acute
gastroenteritis worldwide. We previously demonstrated human intestinal stem cell-derived …

Globally, most cases of gastroenteritis are caused by pandemic GII. 4 human norovirus
(HuNoV) strains with no approved therapies or vaccines available. The cellular pathways …

Human noroviruses (HuNoVs) are the leading cause of viral gastroenteritis worldwide; yet
currently, no vaccines or FDA-approved antiviral drugs are available to counter these …

Understanding the complex interactions between virus and host that drive new strain
evolution is key to predicting the emergence potential of variants and informing vaccine …

Laboratory studies of host–microbe interactions have historically been carried out using
transformed cell lines and animal models. Although much has been learned from these …

A key to improving vaccine design and vaccination strategy is to understand the mechanism
behind the variation of vaccine response with host factors. Glycosylation, a critical modulator …

Norovirus is the leading cause of epidemic and endemic acute gastroenteritis worldwide
and the most frequent cause of foodborne illness in the United States. There is no specific …

A GII. 2 outbreak in an efficacy study of a bivalent virus-like particle norovirus vaccine, TAK-
214, in healthy US adults provided an opportunity to examine GII. 4 homotypic vs GII. 2 …