Technical advances at the interface of biology and computation, such as single-cell RNA-
sequencing (scRNA-seq), reveal new layers of complexity in cellular systems. An emerging …

Background Single-cell metabolic studies bring new insights into cellular function, which can
often not be captured on other omics layers. Metabolic information has wide applicability …

Motivation Gene regulation is responsible for controlling numerous physiological functions
and dynamically responding to environmental fluctuations. Reconstructing the human …

Pediatric patients with recurrent and refractory cancers are in most need for new treatments.
This study developed patient-derived-xenograft (PDX) models within the European …

Multicellular organisms are composed of diverse cell types that must coordinate their
behaviors through communication. Cell–cell communication (CCC) is essential for growth …

Genome-scale metabolic models comprehensively describe an organism's metabolism and
can be tailored using omics data to model condition-specific physiology. The quality of …

Methanotrophy is the ability of an organism to capture and utilize the greenhouse gas,
methane, as a source of energy-rich carbon. Over the years, significant progress has been …

Background Whilst the incidence of neurological diseases is increasing worldwide,
treatment remains mostly limited to symptom management. The gut− brain axis, which …

Crosstalk among cells is vital for maintaining the biological function and intactness of
systems. Most existing methods for investigating cell-cell communications are based on …

Metabolism governs cell performance in biomanufacturing, as it fuels growth and
productivity. However, even in well-controlled culture systems, metabolism is dynamic, with …