[HTML][HTML] A narrative review: CXC chemokines influence immune surveillance in obesity and obesity-related diseases: Type 2 diabetes and nonalcoholic fatty liver …
Adipose tissue develops lipids, aberrant adipokines, chemokines, and pro-inflammatory
cytokines as a consequence of the low-grade systemic inflammation that characterizes …
cytokines as a consequence of the low-grade systemic inflammation that characterizes …
[HTML][HTML] Role of β-catenin activation in the tumor immune microenvironment and immunotherapy of hepatocellular carcinoma
M Morita, N Nishida, T Aoki, H Chishina, M Takita… - Cancers, 2023 - mdpi.com
Simple Summary The response rate to immune checkpoint inhibitor (ICI) monotherapy in
hepatocellular carcinoma (HCC) is as low as 20%; therefore, it is important to identify the …
hepatocellular carcinoma (HCC) is as low as 20%; therefore, it is important to identify the …
[HTML][HTML] A gut bacterial signature in blood and liver tissue characterizes cirrhosis and hepatocellular carcinoma
M Effenberger, S Waschina, C Bronowski… - Hepatology …, 2023 - journals.lww.com
Background: HCC is the leading cause of cancer in chronic liver disease. A growing body of
experimental mouse models supports the notion that gut-resident and liver-resident …
experimental mouse models supports the notion that gut-resident and liver-resident …
[HTML][HTML] TP53 R249S mutation in hepatic organoids captures the predisposing cancer risk
TP53 R249S mutation in hepatic organoids captures the predis... : Hepatology TP53 R249S
mutation in hepatic organoids captures the predisposing cancer risk : Hepatology AASLD …
mutation in hepatic organoids captures the predisposing cancer risk : Hepatology AASLD …
MYC in liver cancer: mechanisms and targeted therapy opportunities
F Liu, Z Liao, Z Zhang - Oncogene, 2023 - nature.com
MYC, a major oncogenic transcription factor, regulates target genes involved in various
pathways such as cell proliferation, metabolism and immune evasion, playing a critical role …
pathways such as cell proliferation, metabolism and immune evasion, playing a critical role …
[HTML][HTML] Differential methylation patterns in lean and obese non-alcoholic steatohepatitis-associated hepatocellular carcinoma
E Hymel, KW Fisher, PA Farazi - BMC cancer, 2022 - Springer
Background Nonalcoholic fatty liver disease affects about 24% of the world's population and
may progress to nonalcoholic steatohepatitis (NASH), cirrhosis, and hepatocellular …
may progress to nonalcoholic steatohepatitis (NASH), cirrhosis, and hepatocellular …
[HTML][HTML] The association between tumour heterogeneity and immune evasion mechanisms in hepatocellular carcinoma and its clinical implications
Hepatocellular carcinoma (HCC) is the third leading cause of cancer-related mortality
worldwide. The emergence of combination therapy, atezolizumab (anti-PDL1, immune …
worldwide. The emergence of combination therapy, atezolizumab (anti-PDL1, immune …
[HTML][HTML] Metabolic reprogramming in the tumor microenvironment of liver cancer
J Lin, D Rao, M Zhang, Q Gao - Journal of Hematology & Oncology, 2024 - Springer
The liver is essential for metabolic homeostasis. The onset of liver cancer is often
accompanied by dysregulated liver function, leading to metabolic rearrangements …
accompanied by dysregulated liver function, leading to metabolic rearrangements …
[HTML][HTML] Multi-Omics profiling identifies aldehyde dehydrogenase 2 as a critical mediator in the crosstalk between Treg-mediated immunosuppression …
ZY Liu, XH Lin, HY Guo, X Shi, DY Zhang… - … Journal of Biological …, 2024 - ncbi.nlm.nih.gov
Dysregulation of the aldehyde dehydrogenase (ALDH) family has been implicated in various
pathological conditions, including cancer. However, a systematic evaluation of ALDH …
pathological conditions, including cancer. However, a systematic evaluation of ALDH …
[HTML][HTML] Identification and validation of a costimulatory molecule-related signature to predict the prognosis for uveal melanoma patients
M Zhao, Y Yu, Z Song - Scientific Reports, 2024 - nature.com
Uveal melanoma (UVM) is the most common primary tumor in adult human eyes.
Costimulatory molecules (CMs) are important in maintaining T cell biological functions and …
Costimulatory molecules (CMs) are important in maintaining T cell biological functions and …