Hydrogels as functional components in artificial cell systems

ME Allen, JW Hindley, DK Baxani, O Ces… - Nature Reviews …, 2022 - nature.com
Recent years have seen substantial efforts aimed at constructing artificial cells from various
molecular components with the aim of mimicking the processes, behaviours and …

Protocells: Milestones and recent advances

I Gözen, ES Köksal, I Põldsalu, L Xue, K Spustova… - Small, 2022 - Wiley Online Library
The origin of life is still one of humankind's great mysteries. At the transition between
nonliving and living matter, protocells, initially featureless aggregates of abiotic matter, gain …

Droplet-based microfluidics in biomedical applications

L Amirifar, M Besanjideh, R Nasiri, A Shamloo… - …, 2022 - iopscience.iop.org
Droplet-based microfluidic systems have been employed to manipulate discrete fluid
volumes with immiscible phases. Creating the fluid droplets at microscale has led to a …

Multi-responsive hydrogel structures from patterned droplet networks

FG Downs, DJ Lunn, MJ Booth, JB Sauer… - Nature …, 2020 - nature.com
Responsive hydrogels that undergo controlled shape changes in response to a range of
stimuli are of interest for microscale soft robotic and biomedical devices. However, these …

Signal processing and generation of bioactive nitric oxide in a model prototissue

S Liu, Y Zhang, X He, M Li, J Huang, X Yang… - Nature …, 2022 - nature.com
The design and construction of synthetic prototissues from integrated assemblies of artificial
protocells is an important challenge for synthetic biology and bioengineering. Here we …

Hierarchical self-assembly of a copolymer-stabilized coacervate protocell

AF Mason, BC Buddingh', DS Williams… - Journal of the …, 2017 - ACS Publications
Complex coacervate microdroplets are finding increased utility in synthetic cell applications
due to their cytomimetic properties. However, their intrinsic membrane-free nature results in …

Microfluidics for biosynthesizing: from droplets and vesicles to artificial cells

Y Ai, R Xie, J Xiong, Q Liang - Small, 2020 - Wiley Online Library
Fabrication of artificial biomimetic materials has attracted abundant attention. As one of the
subcategories of biomimetic materials, artificial cells are highly significant for multiple …

Engineering compartmentalized biomimetic micro-and nanocontainers

T Trantidou, M Friddin, Y Elani, NJ Brooks, RV Law… - Acs Nano, 2017 - ACS Publications
Compartmentalization of biological content and function is a key architectural feature in
biology, where membrane bound micro-and nanocompartments are used for performing a …

Recent Advances in Microfluidic Technologies for the Construction of Artificial Cells

S Tan, Y Ai, X Yin, Z Xue, X Fang… - Advanced Functional …, 2023 - Wiley Online Library
Artificial cells are synthetic constructs that emulate natural cells, with potential applications in
areas of energy science, environmental treatment, and the study of life's origins …

Concurrent drug unplugging and permeabilization of polyprodrug‐gated crosslinked vesicles for cancer combination chemotherapy

X Hu, S Zhai, G Liu, D Xing, H Liang… - Advanced Materials, 2018 - Wiley Online Library
Combination chemotherapy with both hydrophobic and hydrophilic therapeutic drugs is
clinically vital toward the treatment of persistent cancers. Though conventional liposomes …