Squalene is a natural triterpene and an important intermediate of sterol and hopanoid
biosynthesis in various types of cell from bacteria to human. Synthesis and further …

Understanding how membrane lipids achieve their non-random distribution in cells is a key
challenge in cell biology at present. In addition to being sorted into vesicles that can cross …

Modern medicine faces the challenge of developing safer and more effective therapies to
treat human diseases. Many drugs currently in use were discovered without knowledge of …

Recent studies have revealed the presence of intracellular lipid droplets in wide variety of
species. In mammalian cells, there exist proteins specifically localize in lipid droplets …

Many prokaryotes are able to accumulate large amounts of lipophilic compounds as
inclusion bodies in the cytoplasm. Members of most genera synthesize polymeric lipids such …

The single cell eukaryote Saccharomyces cerevisiae is an attractive model to study the
complex process of neutral lipid (triacylglycerol and steryl ester) synthesis, storage and …

The oligomeric lipid raft-associated integral protein stomatin normally localizes to the
plasma membrane and the late endosomal compartment. Similar to the caveolins, it is …

Intracellular trafficking is not mediated exclusively by vesicles. Additional, non-vesicular
mechanisms transport material, in particular small molecules such as lipids and Ca 2+ ions …

Mammalian lipid droplets (LDs) are specialized cytosolic organelles consisting of a neutral
lipid core surrounded by a membrane made up of a phospholipid monolayer and a specific …

Lipid particles (LP) of all types of cells are a depot of neutral lipids. The present investigation
deals with the isolation of LP from the yeast Yarrowia lipolytica and the characterization of …