Recent advances in therapeutic targets identification and development of treatment strategies towards Pseudomonas aeruginosa infections
DRA Sanya, D Onésime, G Vizzarro, N Jacquier - BMC microbiology, 2023 - Springer
The opportunistic human pathogen Pseudomonas aeruginosa is the causal agent of a wide
variety of infections. This non-fermentative Gram-negative bacillus can colonize zones …
variety of infections. This non-fermentative Gram-negative bacillus can colonize zones …
[HTML][HTML] Battle royale: immune response on biofilms–host-pathogen interactions
SP Cangui-Panchi, AL Ñacato-Toapanta… - Current research in …, 2023 - Elsevier
The research interest of the scientific community in biofilm-forming microorganisms is
growing due to the problems caused by their infections affecting humans and animals …
growing due to the problems caused by their infections affecting humans and animals …
Moonlighting chaperone activity of the enzyme PqsE contributes to RhlR-controlled virulence of Pseudomonas aeruginosa
SR Borgert, S Henke, F Witzgall, S Schmelz… - Nature …, 2022 - nature.com
Pseudomonas aeruginosa is a major cause of nosocomial infections and also leads to
severe exacerbations in cystic fibrosis or chronic obstructive pulmonary disease. Three …
severe exacerbations in cystic fibrosis or chronic obstructive pulmonary disease. Three …
An expanded CRISPR–Cas9-assisted recombineering toolkit for engineering genetically intractable Pseudomonas aeruginosa isolates
D Pankratz, NO Gomez, A Nielsen, A Mustafayeva… - Nature protocols, 2023 - nature.com
Much of our current understanding of microbiology is based on the application of genetic
engineering procedures. Since their inception (more than 30 years ago), methods based …
engineering procedures. Since their inception (more than 30 years ago), methods based …
Precise genome engineering in Pseudomonas using phage-encoded homologous recombination and the Cascade–Cas3 system
W Zheng, Y Xia, X Wang, S Gao, D Zhou… - Nature …, 2023 - nature.com
A lack of generic and effective genetic manipulation methods for Pseudomonas has
restricted fundamental research and utilization of this genus for biotechnology applications …
restricted fundamental research and utilization of this genus for biotechnology applications …
Tackling recalcitrant Pseudomonas aeruginosa infections in critical illness via anti-virulence monotherapy
Intestinal barrier derangement allows intestinal bacteria and their products to translocate to
the systemic circulation. Pseudomonas aeruginosa (PA) superimposed infection in critically …
the systemic circulation. Pseudomonas aeruginosa (PA) superimposed infection in critically …
The end of the reign of a “master regulator''? A defect in function of the LasR quorum sensing regulator is a common feature of Pseudomonas aeruginosa isolates
Pseudomonas aeruginosa, a bacterium causing infections in immunocompromised
individuals, regulates several of its virulence functions using three interlinked quorum …
individuals, regulates several of its virulence functions using three interlinked quorum …
A comprehensive review of genomics, transcriptomics, proteomics, and metabolomic insights into the differentiation of Pseudomonas aeruginosa from the planktonic …
Biofilm formation by Pseudomonas aeruginosa is primarily responsible for chronic wound
and lung infections in humans. These infections are persistent owing to the biofilm's high …
and lung infections in humans. These infections are persistent owing to the biofilm's high …
Evolution of Quorum Sensing in Pseudomonas aeruginosa Can Occur via Loss of Function and Regulon Modulation
P Jayakumar, ART Figueiredo, R Kümmerli - Msystems, 2022 - Am Soc Microbiol
Pseudomonas aeruginosa populations evolving in cystic fibrosis lungs, animal hosts, natural
environments and in vitro undergo extensive genetic adaption and diversification. A …
environments and in vitro undergo extensive genetic adaption and diversification. A …
Transcriptome dynamics of pseudomonas aeruginosa during transition from overlapping to non-overlapping cell cycles
K Alpers, E Vatareck, L Gröbe, M Müsken, M Scharfe… - Msystems, 2023 - Am Soc Microbiol
Bacteria either duplicate their chromosome once per cell division or a new round of
replication is initiated before the cells divide, thus cell cycles overlap. Here, we show that the …
replication is initiated before the cells divide, thus cell cycles overlap. Here, we show that the …