Activated hepatic stellate cells (HSCs) and myofibroblasts are the main producers of
extracellular matrix (ECM) proteins that form the fibrotic tissue that leads to hepatic fibrosis …

This review examines the generation of reactive oxygen species by mammalian
mitochondria, and the status of different sites of production in redox signaling and pathology …

Alcoholic liver disease (ALD) is a complex process that includes a wide spectrum of hepatic
lesions, from steatosis to cirrhosis. Cell injury, inflammation, oxidative stress, regeneration …

Mitochondria are the main source of reactive oxygen species (ROS), most of them deriving
from the mitochondrial respiratory chain. Among the numerous enzymatic and non …

Reactive oxygen species (ROS) and reactive nitrogen species (RNS) are generated from
aerobic metabolism, as a result of accidental electron leakage as well as regulated …

Reactive oxygen species (ROS) are continuously generated within living systems and the
inability to manage ROS load leads to elevated oxidative stress and cell damage. Oxidative …

Sepsis-related organ dysfunction remains the most common cause of death in the intensive
care unit (ICU), despite advances in healthcare and science. Marked oxidative stress as a …

Irrespective of the morphological features of end-stage cell death (that may be apoptotic,
necrotic, autophagic, or mitotic), mitochondrial membrane permeabilization (MMP) is …

Mitochondria are the primary intracellular site of oxygen consumption and the major source
of reactive oxygen species (ROS), most of them originating from the mitochondrial …

Reactive oxygen species (ROS) are small, highly reactive, oxygen-containing molecules that
are naturally generated in small amounts during the body's metabolic reactions and can …