Pathogenic fungi have become a leading cause of human mortality due to the increasing
frequency of fungal infections in immunocompromised populations and the limited …

Although Cryptococcus neoformans and cryptococcosis have existed for several millennia, a
century has passed since the discovery of this encapsulated yeast and its devastating …

Fungi cause serious infections in the immunocompromised and debilitated, and the
incidence of invasive mycoses has increased significantly over the last 3 decades. Slow …

MATERIALS AND METHODS Strains and media. C. neoformans var. grubii strains H99 (70),
KN99a (55), KN99 (55), KN99aNAT, and KN99NAT were maintained at 80 C. Cultures were …

Cellular differentiation, mating, and filamentous growth are regulated in many fungi by
environmental and nutritional signals. For example, in response to nitrogen limitation …

Capsule formation plays a significant role in the pathogenicity of Cryptococcus neoformans.
To study the molecular basis of capsule synthesis, the capsule-deficient phenotype of a …

Evaluation of Cryptococcus neoformans virulence in a number of nonmammalian hosts
suggests that C. neoformans is a nonspecific pathogen. We used the killing of Galleria …

Cryptococcus neoformans and Cryptococcus gattii are closely related pathogenic fungi that
cause pneumonia and meningitis in both immunocompromised and immunocompetent …

Cryptococcus neoformans is a major cause of fungal meningoencephalitis in
immunocompromised patients. Despite recent advances in the genetics and molecular …

Cryptococcus neoformans is a human-pathogenic fungus that has evolved into three distinct
varieties that infect most prominently the central nervous system. A sexual cycle involving …