It is increasingly appreciated that the acidic microenvironment of a tumour contributes to its
evolution and clinical outcomes. However, our understanding of the mechanisms by which …

Acid-sensing ion channel 1a (ASIC1a), a prominent member of the acid-sensing ion channel
(ASIC) superfamily activated by extracellular protons, is ubiquitously expressed throughout …

The microenvironment of proliferative and aggressive tumours, such as the brain tumour
glioblastoma multiforme (GBM), is often acidic, hypoxic, and nutrient deficient. Acid-sensing …

Acid-sensing ion channels (ASICs) are Na+ channels that are almost ubiquitously
expressed in neurons of the brain. Functional ASIC1a is also expressed in glioblastoma …

Fast growing solid tumors are frequently surrounded by an acidic microenvironment. Tumor
cells employ a variety of mechanisms to survive and proliferate under these harsh …

BACKGROUND: Osteosarcoma (OS) is a relatively rare malignant bone tumor in teenagers;
however, its molecular mechanisms are not yet understood comprehensively. OBJECTIVE …

Acidosis is a central feature of many pathological conditions, and while the activity of many
ion channels is suppressed under acidic conditions, acid-sensing ion channels (ASICs) are …

The microenvironment of proliferative and aggressive tumours, such as the brain tumour
glioblastoma multiforme (GBM), is often acidic, hypoxic, and nutrient deficient. Acid-sensing …

In this thesis, it has been demonstrated, that the activity of Acid-sensing ion channel 1a
(ASIC1a) is critically affected by Prenylcysteine oxidase-like (PCOL). PCOL strongly …