Sex differences in colorectal cancer: with a focus on sex hormone–gut microbiome axis

Z Wu, Y Huang, R Zhang, C Zheng, F You… - Cell Communication and …, 2024 - Springer
Sexual dimorphism has been observed in the incidence and prognosis of colorectal cancer
(CRC), with men generally exhibiting a slightly higher incidence than women. Research …

Sex-specific outcomes in cancer therapy: the central role of hormones

P Bakhshi, JQ Ho, S Zanganeh - Frontiers in Medical Technology, 2024 - frontiersin.org
Sex hormones play a pivotal role in modulating various physiological processes, with
emerging evidence underscoring their influence on cancer progression and treatment …

[HTML][HTML] Plasma exosome-derived circGAPVD1 as a potential diagnostic marker for colorectal cancer

T Li, T Zhou, J Wu, H Lv, H Zhou, M Du, X Zhang… - Translational …, 2023 - Elsevier
Abstract Background Although circular RNAs (circRNAs) have recently garnered interest as
disease markers, they have been relatively poorly studied as a biomarker in colorectal …

Genetic Modulation of BET1L Confers Colorectal Cancer Susceptibility by Reducing miRNA Binding and m6A Modification

S Li, M Du, K Xu, S Ben, T Zhu, M Guo, J Xin… - Cancer …, 2023 - aacrjournals.org
Genetic variants in regions encoding 3′ untranslated regions (UTR) of mRNA potentially
alter miRNA binding affinity and N6-methyladenosine (m6A) levels to affect gene …

[HTML][HTML] Opposite estrogen effects of estrone and 2-hydroxyestrone on MCF-7 sensitivity to the cytotoxic action of cell growth, oxidative stress and inflammation activity

S Xu, J Sun, Y Zhang, J Ji, X Sun - Ecotoxicology and Environmental Safety, 2021 - Elsevier
There are many kinds of estrogens, and endogenous estrogens produce a variety of
estrogen metabolites with similar structure but with different physiological effects after …

Molecular diversity and biochemical content in two invasive alien species: looking for chemical similarities and bioactivities

J Vega, TS Catalá, J García-Márquez, LG Speidel… - Marine Drugs, 2022 - mdpi.com
The biochemical composition, molecular diversity, and two different bioactivities of
Asparagopsis armata and Rugulopteryx okamurae (two alien species with different invasive …

Considering hormone-sensitive cancers as a single disease in the UK biobank reveals shared aetiology

M Ahmed, VP Mäkinen, A Mulugeta, J Shin… - Communications …, 2022 - nature.com
Hormone-related cancers, including cancers of the breast, prostate, ovaries, uterine, and
thyroid, globally contribute to the majority of cancer incidence. We hypothesize that hormone …

Evaluation and prediction analysis of 3-and 5-year survival rates of patients with cecal adenocarcinoma based on period analysis

Z Shao, S Zheng, C Chen, J Lyu - International Journal of General …, 2021 - Taylor & Francis
Background Cecal adenocarcinoma has a high degree of malignancy and poor prognosis,
thereby bringing serious disease burden to patients. The long-term survival rate of patients …

Future prospects of colorectal cancer screening: Characterizing interval cancers

G Ibáñez-Sanz, R Sanz-Pamplona, M Garcia… - Cancers, 2021 - mdpi.com
Simple Summary The number of interval colorectal cancers is an intermediate measure of
the effectiveness of a population-screening programme in decreasing colorectal cancer …

Impact of Estrogen Metabolites on MCF-7 Breast Cancer Cells: Insights from Metabolomics Study

J Ji, X Gao, Y Ye, N Yadikar, S Xu, J Sun, Y Zhang… - Food Bioscience, 2024 - Elsevier
In addition to being highly stable, estrogen is widely available in the environment, food, and
produce various metabolites such as 2-hydroxyestrone (2-OH-E1), 2-methoxyestrone (2 …