The mechanisms that maintain the stability of chromosome ends have broad impact on
genome integrity in all eukaryotes. Budding yeast is a premier organism for telomere …

Telomerase is the essential reverse transcriptase required for linear chromosome
maintenance in most eukaryotes. Telomerase supplements the tandem array of simple …

Telomeres with G-rich repetitive DNA and particular proteins as special heterochromatin
structures at the termini of eukaryotic chromosomes are tightly maintained to safeguard …

Elongation of a short telomere depends on the action of multiple telomerase molecules,
which are visible as telomerase RNA foci or clusters associated with telomeres in yeast and …

Telomeres are dynamic nucleoprotein structures that protect the ends of chromosomes from
degradation and activation of DNA damage response. For this reason, telomeres are …

The eukaryotic genome is replicated according to a specific spatio‐temporal programme.
However, little is known about both its molecular control and biological significance. Here …

Telomerase maintains genome integrity by adding repetitive DNA sequences to the
chromosome ends in actively dividing cells, including 90% of all cancer cells. Recruitment of …

Chromosome breakage is a major threat to genome integrity. The most accurate way to
repair DNA double strand breaks (DSB) is homologous recombination (HR) with an intact …

Telomerase adds simple-sequence repeats to the ends of linear chromosomes to counteract
the loss of end sequence inherent in conventional DNA replication. Catalytic activity for …

Telomeres are the physical ends of eukaryotic chromosomes. They protect chromosome
ends from DNA degradation, recombination, and DNA end fusions, and they are important …