The Ehlers‒Danlos syndromes (EDS) constitute a heterogenous group of connective tissue
disorders characterized by joint hypermobility, skin abnormalities, and vascular fragility. The …

Osteoarthritis (OA), one of the most common degenerative diseases, is characterized by
progressive degeneration of the articular cartilage and subchondral bone, as well as the …

Osteoarthritis (OA) is a chronic progressive articular illness which commonly affects older‑
aged adults, presenting with cartilage inflammation and degradation. Rutaecarpine (RUT) …

Abstract Objectives Extracellular vesicles (EVs) from rheumatoid arthritis (RA) synovial fluid
(SF) have been reported to stimulate the release of pro‐inflammatory mediators from …

Osteoarthritis (OA) is a common articular ailment presented with cartilage loss and
destruction that is common observed in the elderly population. Physalin A (PA), a natural …

In primary or idiopathic osteoarthritis (OA), it is unclear which factors trigger the shift of
articular chondrocyte activity from pro-anabolic to pro-catabolic. In fact, there is a controversy …

Purpose The aim of this study was to analyze local and systematic inflammatory status in
knee osteoarthritis (KOA), focusing on intra-articular and remote adipose tissue depots, and …

STR/ort mice spontaneously exhibit the typical osteoarthritis (OA) phenotype. However,
studies describing the relationship between cartilage histology, epiphyseal trabecular bone …

Introduction Osteoarthritis (OA) is a prevalent joint disease that severely impacts patients'
quality of life. Due to its unclear pathogenesis and lack of effective therapeutic targets …

Aims Therapeutic agents that prevent chondrocyte loss, extracellular matrix (ECM)
degradation, and osteoarthritis (OA) progression are required. The expression level of …