Autophagy is a delicate intracellular degradation process that occurs due to diverse stressful
conditions, including the accumulation of damaged proteins and organelles as well as …

Autophagy is a highly conserved cellular process by which cytoplasmic components are
sequestered in autophagosomes and delivered to lysosomes for degradation. As a major …

Human mesenchymal stem/stromal cells (hMSCs) have been shown to support breast
cancer cell proliferation and metastasis, partly through their secretome. hMSCs have a …

Serum starvation is one of the most frequently performed procedures in molecular biology
and there are literally thousands of research papers reporting its use. In fact, this method has …

Mesenchymal stem cells (MSC) have become a promising tool for therapeutic intervention.
Their unique features, including self-renewal, multipotency and immunomodulatory …

Mesenchymal stem cells (MSCs) play an important role in chemoresistance. Exosomes have
been reported to modify cellular phenotype and function by mediating cell-cell …

Current evidence suggests a central role for autophagy in Alzheimer disease (AD), and
dysfunction in the autophagic system may lead to amyloid-β (Aβ) accumulation. Using in …

Cytotoxic drugs remain the first-line option for cancer therapy but the development of drug-
resistance by tumor cells represents a primary obstacle for successful chemotherapy …

Notch signaling is an evolutionarily conserved pathway involved in cell fate control during
development, stem cell self-renewal, and postnatal tissue differentiation. Roles for Notch in …

The emerging concept of cancer stem cells (CSCs) as the key driver behind carcinogenesis,
progression, and diversity has displaced the prior model of a tumor composed of cells with …