Major apoptotic mechanisms and genes involved in apoptosis
As much as the cellular viability is important for the living organisms, the elimination of
unnecessary or damaged cells has the opposite necessity for the maintenance of …
unnecessary or damaged cells has the opposite necessity for the maintenance of …
Targeting tumor-associated fibroblasts for therapeutic delivery in desmoplastic tumors
The off-target distribution of anticancer nanoparticles to fibroblasts creates a barrier to the
effective treatment of desmoplastic tumors. However, we hypothesized that this nanoparticle …
effective treatment of desmoplastic tumors. However, we hypothesized that this nanoparticle …
The TRAIL to cancer therapy: Hindrances and potential solutions
Apoptosis is an ordered and orchestrated cellular process that occurs in physiological and
pathological conditions. Resistance to apoptosis is a hallmark of virtually all malignancies …
pathological conditions. Resistance to apoptosis is a hallmark of virtually all malignancies …
Modulating tumor-associated macrophages to enhance the efficacy of immune checkpoint inhibitors: A TAM-pting approach
AN Chamseddine, T Assi, O Mir, S Chouaib - Pharmacology & therapeutics, 2022 - Elsevier
Tumor-associated macrophages (TAM) plasticity and diversity are both essential hallmarks
of the monocyte-macrophage lineage and the tumor-derived inflammation. TAM exemplify …
of the monocyte-macrophage lineage and the tumor-derived inflammation. TAM exemplify …
Mechanisms of apoptosis resistance to NK cell-mediated cytotoxicity in cancer
C Sordo-Bahamonde, S Lorenzo-Herrero… - International journal of …, 2020 - mdpi.com
Natural killer (NK) cells are major contributors to immunosurveillance and control of tumor
development by inducing apoptosis of malignant cells. Among the main mechanisms …
development by inducing apoptosis of malignant cells. Among the main mechanisms …
Curcumol overcomes TRAIL resistance of non‐small cell lung cancer by targeting NRH: quinone oxidoreductase 2 (NQO2)
J Zhang, Y Zhou, N Li, WT Liu, JZ Liang… - Advanced …, 2020 - Wiley Online Library
Resistance to tumor‐necrosis‐factor‐related apoptosis‐inducing ligand (TRAIL) of cancer
cell remains a key obstacle for clinical cancer therapies. To overcome TRAIL resistance, this …
cell remains a key obstacle for clinical cancer therapies. To overcome TRAIL resistance, this …
Novel apoptosis-inducing agents for the treatment of cancer, a new arsenal in the toolbox
B Lim, Y Greer, S Lipkowitz, N Takebe - Cancers, 2019 - mdpi.com
Evasion from apoptosis is an important hallmark of cancer cells. Alterations of apoptosis
pathways are especially critical as they confer resistance to conventional anti-cancer …
pathways are especially critical as they confer resistance to conventional anti-cancer …
TRAILblazing strategies for cancer treatment
AL Kretz, A Trauzold, A Hillenbrand, U Knippschild… - Cancers, 2019 - mdpi.com
In the late 1990s, tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL), a
member of the TNF-family, started receiving much attention for its potential in cancer …
member of the TNF-family, started receiving much attention for its potential in cancer …
Physical tuning of galectin-3 signaling
Galectin-3 (Gal3) exhibits dynamic oligomerization and promiscuous binding, which can
lead to concomitant activation of synergistic, antagonistic, or noncooperative signaling …
lead to concomitant activation of synergistic, antagonistic, or noncooperative signaling …