The prefrontal cortex (PFC) has emerged as one of the regions most consistently impaired in
major depressive disorder (MDD). Although functional and structural PFC abnormalities …

Abstract ARNSTEN, AFT, MKP Joyce and AC Roberts. The Aversive Lens: Stress effects on
the prefrontal-cingulate cortical pathways that regulate emotion. NEUROSCI BIOBEHAV …

Neuroimaging studies implicate the ventromedial prefrontal cortex (vmPFC) in a wide range
of emotional and cognitive functions, and changes in activity within vmPFC have been linked …

A crucial component of social cognition is to observe and understand the social interactions
of other individuals. A promising nonhuman primate model for investigating the neural basis …

Recent years have seen a profound resurgence of activity with nonhuman primates (NHPs)
to model human brain disorders. From marmosets to macaques, the study of NHP species …

Accurately estimating safety is critical to pursuing nondefensive survival behaviors.
However, little attention has been paid to how the human brain computes safety. We …

Impaired detection of causal relationships between actions and their outcomes can lead to
maladaptive behavior. However, causal roles of specific prefrontal cortex (PFC) sub-regions …

Aberrant activity in caudal subcallosal anterior cingulate cortex (scACC) is implicated in
depression and anxiety symptomatology, with its normalisation a putative biomarker of …

Structural and functional abnormalities of the orbitofrontal cortex (OFC) have been
implicated in affective disorders that manifest anxiety-related symptoms. However, research …

Compared with that of even the closest primates, the human cortex displays a high degree of
specialization and expansion that largely emerges developmentally. Although decades of …