The severity of human infection by one of the many Shiga toxin-producing Escherichia coli
(STEC) is determined by a number of factors: the bacterial genome, the capacity of human …

Onconephrology is a new subspecialty of nephrology that recognizes the important
intersections of kidney disease with cancer. This intersection takes many forms and includes …

Adeno-associated virus (AAV) gene therapies are highly promising, such as the
onasemnogene abeparvovec (Zolgensma) in spinal muscle atrophy (SMA). We report the …

Studies of complement genetics have changed the landscape of thrombotic
microangiopathies (TMAs), particularly atypical haemolytic uraemic syndrome (aHUS) …

The primary causes of chronic kidney disease (CKD) in children differ from those of CKD in
adults. In the USA the most common diagnostic groups of renal disease that manifest before …

The hemolytic–uremic syndrome, which is characterized by nonimmune hemolytic anemia,
thrombocytopenia, and renal impairment, occurs most frequently in young children. Most …

To define the role of rare variants in advanced age-related macular degeneration (AMD)
risk, we sequenced the exons of 681 genes within all reported AMD loci and related …

The crosstalk among the complement system, immune cells, and mediators of inflammation
provides an efficient mechanism to protect the organism against infections and support the …

Most cases of diarrhoea-associated haemolytic uraemic syndrome (HUS) are caused by
Shiga-toxin-producing bacteria; the pathophysiology differs from that of thrombotic …

Haemolytic uraemic syndrome (HUS) and thrombotic thrombocytopaenic purpura (TTP) are
diseases characterized by microvascular thrombosis, with consequent thrombocytopaenia …