The current paradigm of onset and progression of periodontitis includes oral dysbiosis
directed by inflammophilic bacteria, leading to altered resolution of inflammation and lack of …

Both genetic background and environmental factors, very probably viruses, appear to play a
role in the etiology of multiple sclerosis (MS). Lessons from viral experimental models …

CD4+ CD25+ regulatory T cells contribute to the maintenance of peripheral tolerance by
active suppression because their deletion causes spontaneous autoimmune diseases in …

Autoimmune gastritis and Helicobacter pylori–associated gastric atrophy develop through
similar mechanisms involving the proton pump H+, K+–adenosine triphosphatase as …

Autoimmune diseases remain one of the mysteries that perplex immunologists. What makes
the immune system, which has evolved to protect an organism from foreign invaders, turn on …

Lyme disease has a worldwide distribution and is the most common vector-borne disease in
the United States. Incidence, clinical manifestations, and presentations vary by geography …

This volume covers many topics in the field of T‐cell costimulation. The need for such a
volume is testament to the growth of the field. From its beginning as a concept in the 1980s …

Lyme disease, a multisystem spirochetal infection, continues to be the subject of
considerable debate, but not controversy. Recent years have seen improvements in …

Pathogens can induce autoreactive T cells to initiate autoimmune disease by several
mechanisms. Pathogen-induced inflammation results in the enhanced presentation of self …

Clinical observations and experimental evidence link bone marrow failure in
myelodysplastic syndrome (MDS) with a T cell–dominated autoimmune process …