Inflammatory bowel diseases (IBDs), including Crohn's disease and ulcerative colitis are
complex disorders with undetermined etiology. Several hypotheses suggest that IBDs result …

Studies in recent years have identified a pivotal role of the cytokine IL-23 in the
pathogenesis of inflammatory bowel diseases (IBD: Crohn´ s disease, ulcerative colitis) and …

In this review, we focus on the role of oxidative stress in the aetiology of inflammatory bowel
diseases (IBD) and colitis-associated colorectal cancer and discuss free radicals and free …

Th17 and IL‐17 play important roles in the clearance of extracellular bacterial and fungal
infections. However, strong evidence also implicates the Th17 lineage in several …

Ulcerative colitis (UC) is a chronic relapsing disorder of the colonic tract, characterized by a
dysregulated innate and adaptive immune response to gut microbiota that contributes to the …

T cell immunity is essential for the control of tuberculosis (TB), an important disease of the
lung, and is generally studied in humans using peripheral blood cells. Mounting evidence …

The view of CD4 T‐cell‐mediated immunity as a balance between distinct lineages of Th1
and Th2 cells has changed dramatically. Identification of the IL‐17 family of cytokines and of …

Autoimmune diseases (such as rheumatoid arthritis, asthma, autoimmune bowel disease)
are a complex disease. Improper activation of the immune system or imbalance of immune …

Nitric oxide (NO), a signaling molecule, regulates biological functions in multiple
organs/tissues, including the epidermis, where it impacts permeability barrier homeostasis …

Short-chain fatty acids (SCFAs) are metabolites produced mainly by the gut microbiota with
a known role in immune regulation. Acetate, the major SCFA, is described to disseminate to …