Although it is well accepted that the Notch signaling pathway is essential for vascular
morphogenesis, its contributions to the homeostasis of adult endothelium were uncovered …

Blood vessels are constantly exposed to mechanical stimuli such as shear stress due to flow
and pulsatile stretch. The extracellular matrix maintains the structural integrity of the vessel …

Among the numerous molecules that are being studied for their potential utility as
biomarkers of cardiovascular diseases, much interest has been shown in the superfamily of …

Hemodynamic shear forces are intimately linked with cardiac development, during which
trabeculae form a network of branching outgrowths from the myocardium. Mutations that …

Lifestyle and genetic factors can lead to the development of atherosclerosis and, ultimately,
cardiovascular adverse events. Rodent models are commonly used to investigate …

The endothelial surface is a highly flexible signaling hub which is able to sense the
hemodynamic forces of the streaming blood. The subsequent mechanosignaling is basically …

The blood flow through vessels produces a tangential, or shear, stress sensed by their
innermost layer (ie, endothelium) and representing a major hemodynamic force. In humans …

Unloading-mediated muscle atrophy is associated with increased reactive oxygen species
(ROS) production. We previously demonstrated that elevated ubiquitin ligase casitas B …

Interest in recapitulating in vivo phenomena in vitro using organ-on-a-chip technology has
grown rapidly and with it, attention to the types of fluid flow experienced in the body has …

Background. Oscillatory shear stress (OSS) disrupts endothelial homeostasis and promotes
oxidative stress, which can lead to atherosclerosis. In atherosclerotic lesions, Toll‐like …