Radix Bupleuri: A Review of Traditional Uses, Botany, Phytochemistry, Pharmacology, and Toxicology

F Yang, X Dong, X Yin, W Wang… - BioMed Research …, 2017 - Wiley Online Library
Radix Bupleuri (Chaihu) has been used as a traditional medicine for more than 2000 years
in China, Japan, Korea, and other Asian countries. Phytochemical studies demonstrated that …

A comprehensive review and perspectives on pharmacology and toxicology of saikosaponins

X Li, X Li, N Huang, R Liu, R Sun - Phytomedicine, 2018 - Elsevier
Abstract Background Radix Bupleuri (RB) has been widely used in Chinese Traditional
Medicine for over 2000 years and is currently marketed in China as Chai-Hu-Shu-Gan …

JNK signaling as a target for anticancer therapy

KS Abdelrahman, HA Hassan, SA Abdel-Aziz… - Pharmacological …, 2021 - Springer
The JNKs are members of mitogen-activated protein kinases (MAPK) which regulate many
physiological processes including inflammatory responses, macrophages, cell proliferation …

Ethanol extract of Bupleurum falcatum and saikosaponins inhibit neuroinflammation via inhibition of NF-κB

WH Park, S Kang, Y Piao, CJ Pak, MS Oh, J Kim… - Journal of …, 2015 - Elsevier
Ethnopharmacological relevance The root of Bupleurum falcatum L.(BF) has been used in
traditional Korean and Chinese medicines for over 2000 years to treat infections, fever, and …

Saikosaponin‑d inhibits proliferation of DU145 human prostate cancer cells by inducing apoptosis and arresting the cell cycle at G0/G1 phase

M Yao, J Yang, L Cao, L Zhang… - Molecular medicine …, 2014 - spandidos-publications.com
Abstract Saikosaponin‑d (SSd), a triterpene saponin compound derived from Bupleurum
radix, has been shown to have a cytotoxic effect on various cancer cell lines. However, its …

Saikosaponin D inhibits proliferation and promotes apoptosis through activation of MKK4–JNK signaling pathway in pancreatic cancer cells

M Lai, Y Ge, M Chen, S Sun, J Chen… - OncoTargets and …, 2020 - Taylor & Francis
Introduction Pancreatic cancer remains one of the most lethal malignancies and has few
treatment options. Saikosaponin D (SSD), a major bioactive triterpene saponin isolated from …

Chemical and biological comparison of raw and vinegar-baked Radix Bupleuri

ZY Li, HM Sun, J Xing, XM Qin, GH Du - Journal of ethnopharmacology, 2015 - Elsevier
Abstract Ethnopharmacological relevance Radix Bupleuri (RB) is a commonly used herbal
drug in Traditional Chinese Medicine (TCM), and it can be baked with vinegar to afford …

Identification of the original plants of cultivated Bupleuri Radix based on DNA barcoding and chloroplast genome analysis

G Zhang, H Wang, L Shi, Y Liu, R Yao, C Sui, C Yang… - PeerJ, 2022 - peerj.com
Bupleuri Radix is the dry root of certain species of the genus Bupleurum and is commonly
used in traditional Chinese medicine. The increasing global demand for Bupleuri Radix …

Effects of light deficiency on the accumulation of saikosaponins and the ecophysiological characteristics of wild Bupleurum chinense DC. in China

J Gong, M Liu, S Xu, Y Jiang, Y Pan, Z Zhai… - Industrial crops and …, 2017 - Elsevier
Bupleurum chinense DC. is one of the most important traditional Chinese medicines. Among
its primary pharmacologically active components, saikosaponins play a vital role. We …

Chemical profile-and pharmacokinetics-based investigation of the synergistic property of platycodonis radix in traditional Chinese medicine formula Shengxian …

F Zhang, Q Zhan, S Gao, X Dong, B Jiang, L Sun… - Journal of …, 2014 - Elsevier
Ethnopharmacological relevance To investigate the synergistic property of Platycodonis
Radix (PG) in a classic Traditional Chinese Medicine (TCM) prescription Shengxian …