Severe COVID-19 is marked by a dysregulated myeloid cell compartment
J Schulte-Schrepping, N Reusch, D Paclik, K Baßler… - Cell, 2020 - cell.com
Summary Coronavirus disease 2019 (COVID-19) is a mild to moderate respiratory tract
infection, however, a subset of patients progress to severe disease and respiratory failure …
infection, however, a subset of patients progress to severe disease and respiratory failure …
Ebola virus disease in humans: pathophysiology and immunity
C Muñoz-Fontela, AK McElroy - Marburg-and ebolaviruses: From …, 2017 - Springer
Viruses of the Ebolavirus genus cause sporadic epidemics of severe and systemic febrile
disease that are fueled by human-to-human transmission. Despite the notoriety of …
disease that are fueled by human-to-human transmission. Despite the notoriety of …
Building a better antibody through the Fc: advances and challenges in harnessing antibody Fc effector functions for antiviral protection
BM Gunn, S Bai - Human vaccines & immunotherapeutics, 2021 - Taylor & Francis
Antibodies can provide antiviral protection through neutralization and recruitment of innate
effector functions through the Fc domain. While neutralization has long been appreciated for …
effector functions through the Fc domain. While neutralization has long been appreciated for …
Single-cell profiling of Ebola virus disease in vivo reveals viral and host dynamics
Ebola virus (EBOV) causes epidemics with high mortality yet remains understudied due to
the challenge of experimentation in high-containment and outbreak settings. Here, we used …
the challenge of experimentation in high-containment and outbreak settings. Here, we used …
Ebola vaccine–induced protection in nonhuman primates correlates with antibody specificity and Fc-mediated effects
Although substantial progress has been made with Ebola virus (EBOV) vaccine measures,
the immune correlates of vaccine-mediated protection remain uncertain. Here, five mucosal …
the immune correlates of vaccine-mediated protection remain uncertain. Here, five mucosal …
[HTML][HTML] Multi-platform'omics analysis of human Ebola virus disease pathogenesis
AJ Eisfeld, PJ Halfmann, JP Wendler, JE Kyle… - Cell host & …, 2017 - cell.com
The pathogenesis of human Ebola virus disease (EVD) is complex. EVD is characterized by
high levels of virus replication and dissemination, dysregulated immune responses …
high levels of virus replication and dissemination, dysregulated immune responses …
Natural history of Sudan ebolavirus infection in rhesus and cynomolgus macaques
Due to its high mortality rate and continued re-emergence, Ebolavirus disease (EVD)
continues to pose a serious threat to global health. A group of viruses within the genus …
continues to pose a serious threat to global health. A group of viruses within the genus …
HIV vaccine candidate activation of hypoxia and the inflammasome in CD14+ monocytes is associated with a decreased risk of SIVmac251 acquisition
Qualitative differences in the innate and adaptive responses elicited by different HIV vaccine
candidates have not been thoroughly investigated. We tested the ability of the Aventis …
candidates have not been thoroughly investigated. We tested the ability of the Aventis …
Ebola virus–epidemiology, diagnosis, and control: threat to humans, lessons learnt, and preparedness plans–an update on its 40 year's journey
Ebola virus (EBOV) is an extremely contagious pathogen and causes lethal hemorrhagic
fever disease in man and animals. The recently occurred Ebola virus disease (EVD) …
fever disease in man and animals. The recently occurred Ebola virus disease (EVD) …
Nonhuman primate models of Ebola virus disease
RS Bennett, LM Huzella, PB Jahrling… - … -and Ebolaviruses: From …, 2017 - Springer
Ebola virus disease (EVD) in humans is associated with four ebolaviruses: Ebola virus
(EBOV), Sudan virus (SUDV), Bundibugyo virus (BDBV), and Taï Forest virus. To date, no …
(EBOV), Sudan virus (SUDV), Bundibugyo virus (BDBV), and Taï Forest virus. To date, no …