The prefrontal cortex (PFC) has emerged as one of the regions most consistently impaired in
major depressive disorder (MDD). Although functional and structural PFC abnormalities …

Psychiatric disorders encompass complex aberrations of cognition and affect and are
among the most debilitating and poorly understood of any medical condition. Current …

Objective: A role for aberrant reward processing in the pathogenesis of depression has long
been proposed. However, no review has yet examined its role in depression by integrating …

Anhedonia—the loss of pleasure or lack of reactivity to pleasurable stimuli—remains a
formidable treatment challenge across neuropsychiatric disorders. In major depressive …

Ketamine improves motivation-related symptoms in depression but simultaneously elicits
similar symptoms in healthy individuals, suggesting that it might have different effects in …

Rationale/importance Researches have highlighted communication deficits between resting-
state brain networks in major depressive disorder (MDD), as reflected in abnormal functional …

ADHD is a disorder characterized by changes in the reward system and which is highly
comorbid with other mental disorders, suggesting common neurobiological pathways …

'Depression is a common, debilitating, and potentially lethal disorder.'This is a standard
opening to many a scientific paper on depression. And it is often followed by some very grim …

Background Social discrimination, a type of psychological stressor, is associated with poorer
physical and mental health outcomes, yet we have little understanding of how discrimination …

Anhedonia, as evidenced by impaired pleasurable response to reward, reduced reward
motivation, and/or deficits in reward-related learning, is a common feature of depression …