Molecular & genetic factors contributing to insulin resistance in polycystic ovary syndrome

S Mukherjee, A Maitra - Indian Journal of Medical Research, 2010 - journals.lww.com
Polycystic ovary syndrome (PCOS) is the most common endocrine disorder of unknown
etiology. Insulin resistance is very common and plays a central pathogenic role in PCOS …

G allele of the rs1801282 polymorphism in PPARγ gene confers an increased risk of obesity and hypercholesterolemia, while T allele of the rs3856806 polymorphism …

S Li, C He, H Nie, Q Pang, R Wang, Z Zeng… - Frontiers in …, 2022 - frontiersin.org
Background The relationships between the rs1801282 and rs3856806 polymorphisms in
nuclear receptor peroxisome proliferator-activated receptor gamma (PPARγ) gene and …

Insulin resistance and polycystic ovary syndrome

A Galluzzo, MC Amato, C Giordano - Nutrition, Metabolism and …, 2008 - Elsevier
Polycystic ovary syndrome (PCOS) is one of the most common endocrine disorders in
humans, affecting approximately 7–8% of women of reproductive age. Despite the criteria …

The Genetic Basis of the Polycystic Ovary Syndrome: A Literature Review Including Discussion of PPARγ

U Unluturk, A Harmanci, C Kocaefe, BO Yildiz - PPAR research, 2007 - Wiley Online Library
Polycystic ovary syndrome (PCOS) is the most common endocrine disorder of the women of
reproductive age. Familial clustering of PCOS has been consistently reported suggesting …

The role of peroxisome proliferator-activated receptors in polycystic ovary syndrome

I Psilopatis, K Vrettou, E Nousiopoulou… - Journal of Clinical …, 2023 - mdpi.com
Polycystic ovary syndrome (PCOS) constitutes the most common endocrine disorder in
women of reproductive age. Patients usually suffer from severe menstrual irregularities, skin …

Several critical genes and microRNAs associated with the development of polycystic ovary syndrome

W Wang, J Ji, J Li, Q Ren, J Gu, Y Zhao, D Hong… - Annales d' …, 2020 - Elsevier
Background We aimed to identify key genes and microRNAs (miRNAs) associated with the
development of polycystic ovary syndrome (PCOS). Methods GSE84376 mRNA microarray …

PPARγ2Pro12Ala Polymorphism and Human Health

W He - PPAR research, 2009 - Wiley Online Library
The nuclear hormone receptor peroxisome proliferator activated receptor gamma (PPARγ) is
an important transcription factor regulating adipocyte differentiation, lipid and glucose …

Genetic markers of polycystic ovary syndrome: emphasis on insulin resistance

N Shaikh, R Dadachanji… - International Journal of …, 2014 - Wiley Online Library
Polycystic ovary syndrome (PCOS) is the most common endocrinopathy affecting women of
childbearing age causing not only reproductive but also metabolic anomalies. PCOS women …

PPAR gamma: coordinating metabolic and immune contributions to female fertility

CE Minge, RL Robker, RJ Norman - PPAR research, 2008 - Wiley Online Library
Peroxisome proliferator‐activated receptor gamma (PPARG) regulates cellular functions
such as adipogenesis and immune cell activation. However, new information has indicated …

Mediating roles of PPARs in the effects of environmental chemicals on sex steroids

Q Huang, Q Chen - PPAR research, 2017 - Wiley Online Library
Peroxisome proliferator‐activated receptors (PPARs) are ligand‐activated nuclear receptors
that are widely involved in various physiological functions. They are widely expressed …