Oxidative stress as a mechanism for functional alterations in cardiac hypertrophy and heart failure

AK Shah, SK Bhullar, V Elimban, NS Dhalla - Antioxidants, 2021 - mdpi.com
Although heart failure due to a wide variety of pathological stimuli including myocardial
infarction, pressure overload and volume overload is associated with cardiac hypertrophy …

Diabetic cardiomyopathy: Early diagnostic biomarkers, pathogenetic mechanisms, and therapeutic interventions

JL Huo, Q Feng, S Pan, WJ Fu, Z Liu, Z Liu - Cell death discovery, 2023 - nature.com
Diabetic cardiomyopathy (DCM) mainly refers to myocardial metabolic dysfunction caused
by high glucose, and hyperglycemia is an independent risk factor for cardiac function in the …

Curcumin attenuates ferroptosis‐induced myocardial injury in diabetic cardiomyopathy through the Nrf2 pathway

Z Wei, Q Shaohuan, K Pinfang… - Cardiovascular …, 2022 - Wiley Online Library
Diabetes causes lipid peroxide to accumulate within cardiomyocytes. Furthermore, lipid
peroxide buildup is a risk factor for ferroptosis. This study is aimed at examining whether …

The effects of curcumin intake on wound healing and metabolic status in patients with diabetic foot ulcer: A randomized, double‐blind, placebo‐controlled trial

M Mokhtari, R Razzaghi… - Phytotherapy …, 2021 - Wiley Online Library
This study was conducted to determine the effects of curcumin intake on wound healing and
metabolic status in patients with diabetic foot ulcer (DFU). The current randomized, double …

The role of pro-Inflammatory cytokines in the pathogenesis of cardiovascular disease

H Zhang, NS Dhalla - International Journal of Molecular Sciences, 2024 - mdpi.com
With cardiovascular disease (CVD) being a primary source of global morbidity and mortality,
it is crucial that we understand the molecular pathophysiological mechanisms at play …

Oxidative stress signaling mediated pathogenesis of diabetic cardiomyopathy

Z Tang, P Wang, C Dong, J Zhang… - … Medicine and Cellular …, 2022 - Wiley Online Library
As a serious cardiovascular complication, diabetic cardiomyopathy (DCM) refers to diabetes‐
related changes in myocardial structure and function, which is obviously different from those …

Energy substrate metabolism and oxidative stress in metabolic cardiomyopathy

Z Chen, ZX Jin, J Cai, R Li, KQ Deng, YX Ji… - Journal of Molecular …, 2022 - Springer
Metabolic cardiomyopathy is an emerging cause of heart failure in patients with obesity,
insulin resistance, and diabetes. It is characterized by impaired myocardial metabolic …

What is the impact of ferroptosis on diabetic cardiomyopathy: a systematic review

X Lou, Y Zhang, J Guo, L Gao, Y Ding, X Zhuo… - Heart Failure …, 2024 - Springer
Iron overload increases the production of harmful reactive oxygen species in the Fenton
reaction, which causes oxidative stress in the body and lipid peroxidation in the cell …

Curcumin activates Nrf2/HO‐1 signaling to relieve diabetic cardiomyopathy injury by reducing ROS in vitro and in vivo

X Wu, X Zhou, S Lai, J Liu, J Qi - The FASEB Journal, 2022 - Wiley Online Library
The hallmark feature of Diabetes mellitus (DM) is hyperglycemia which can lead to excess
production of reactive oxygen species (ROS) in the myocardium, contributing to diabetic …

The role of mitochondrial abnormalities in diabetic cardiomyopathy

SA Dabravolski, NK Sadykhov, AG Kartuesov… - International Journal of …, 2022 - mdpi.com
Diabetic cardiomyopathy (DCM) is defined as the presence in diabetic patients of abnormal
cardiac structure and performance (such as left ventricular hypertrophy, fibrosis, and …