Solute carriers form one of three major superfamilies of membrane transporters in humans,
and include uniporters, exchangers and symporters. Following several decades of …

The human glycine transporter 1 (GlyT1) regulates glycine-mediated neuronal excitation
and inhibition through the sodium-and chloride-dependent reuptake of glycine,–. Inhibition …

Uncovering the structure and function of biomolecules is a fundamental goal in structural
biology. Membrane‐embedded transport proteins are ubiquitous in all kingdoms of life …

Abstract γ‐aminobutyric acid (GABA) is the major inhibitory neurotransmitter, and its levels in
the synaptic space are controlled by the GABA transporter isoforms (GATs). GATs are …

Serotonin transporter (SERT) plays a fundamental role in taking the synaptic cleft serotonin
back to the presynaptic neuron. The discovery of allosteric SERT modulators represents the …

Neurotransmitter: sodium symporters (NSS) are conserved from bacteria to man and serve
as targets for drugs, including antidepressants and psychostimulants. Here we report the X …

ATB 0,+(SLC6A14) is a member of the amino acid transporter branch of the SLC6 family
along with GlyT1 (SLC6A9) and GlyT2 (SLC6A5), two glycine-specific transporters coupled …

Molecular Dynamics (MD) simulations seek to provide atomic-level insights into
conformationally dynamic biological systems at experimentally relevant time resolutions …

Transport of ions and small molecules across the cell membrane against electrochemical
gradients is catalyzed by integral membrane proteins that use a source of free energy to …

MhsT of Bacillus halodurans is a transporter of hydrophobic amino acids and a homologue
of the eukaryotic SLC6 family of Na+‐dependent symporters for amino acids …