Structure, function and regulation of P-glycoprotein and its clinical relevance in drug disposition
SF Zhou - Xenobiotica, 2008 - Taylor & Francis
1. P-glycoprotein (P-gp/MDR1), one of the most clinically important transmembrane
transporters in humans, is encoded by the ABCB1/MDR1 gene. Recent insights into the …
transporters in humans, is encoded by the ABCB1/MDR1 gene. Recent insights into the …
Cold shock proteins: from cellular mechanisms to pathophysiology and disease
JA Lindquist, PR Mertens - Cell Communication and Signaling, 2018 - Springer
Cold shock proteins are multifunctional RNA/DNA binding proteins, characterized by the
presence of one or more cold shock domains. In humans, the best characterized members of …
presence of one or more cold shock domains. In humans, the best characterized members of …
Inhibition of aldehyde dehydrogenase (ALDH) activity reduces chemotherapy and radiation resistance of stem-like ALDHhiCD44+ human breast cancer cells
AK Croker, AL Allan - Breast cancer research and treatment, 2012 - Springer
The majority of breast cancer deaths are because of ineffective treatment of metastatic
disease. We previously identified a subpopulation of cells in human breast cancer cell lines …
disease. We previously identified a subpopulation of cells in human breast cancer cell lines …
A comprehensive review of the functions of YB-1 in cancer stemness, metastasis and drug resistance
The Y Box binding protein 1 (YB-1) is a member of the highly conserved Cold Shock Domain
protein family with multifunctional properties both in the cytoplasm and inside the nucleus …
protein family with multifunctional properties both in the cytoplasm and inside the nucleus …
Cyclometalated gold (III) complexes containing N‐heterocyclic carbene ligands engage multiple anti‐cancer molecular targets
Metal N‐heterocyclic carbene (NHC) complexes are a promising class of anti‐cancer agents
displaying potent in vitro and in vivo activities. Taking a multi‐faceted approach employing …
displaying potent in vitro and in vivo activities. Taking a multi‐faceted approach employing …
[HTML][HTML] Recent developments in the co-delivery of siRNA and small molecule anticancer drugs for cancer treatment
M Saraswathy, S Gong - Materials Today, 2014 - Elsevier
Because of the complexity of cancer, combination therapy is becoming increasingly
important to overcome multidrug resistance in cancer and to enhance apoptosis. Cancer …
important to overcome multidrug resistance in cancer and to enhance apoptosis. Cancer …
YB-1 as an oncoprotein: functions, regulation, post-translational modifications, and targeted therapy
Q Yin, M Zheng, Q Luo, D Jiang, H Zhang, C Chen - Cells, 2022 - mdpi.com
Y box binding protein 1 (YB-1) is a protein with a highly conserved cold shock domain (CSD)
that also belongs to the family of DNA-and RNA-binding proteins. YB-1 is present in both the …
that also belongs to the family of DNA-and RNA-binding proteins. YB-1 is present in both the …
Oncogenic Y‐box binding protein‐1 as an effective therapeutic target in drug‐resistant cancer
M Kuwano, T Shibata, K Watari, M Ono - Cancer science, 2019 - Wiley Online Library
Y‐box binding protein‐1 (YBX 1), a multifunctional oncoprotein containing an evolutionarily
conserved cold shock domain, dysregulates a wide range of genes involved in cell …
conserved cold shock domain, dysregulates a wide range of genes involved in cell …
Clinical implications of P-glycoprotein modulation in drug–drug interactions
M Lund, TS Petersen, KP Dalhoff - Drugs, 2017 - Springer
Drug–drug interactions (DDIs) occur commonly and may lead to severe adverse drug
reactions if not handled appropriately. Considerable information to support clinical decision …
reactions if not handled appropriately. Considerable information to support clinical decision …
YB-1 is important for late-stage embryonic development, optimal cellular stress responses, and the prevention of premature senescence
ZH Lu, JT Books, TJ Ley - Molecular and cellular biology, 2005 - Taylor & Francis
Proteins containing “cold shock” domains belong to the most evolutionarily conserved family
of nucleic acid-binding proteins known among bacteria, plants, and animals. One of these …
of nucleic acid-binding proteins known among bacteria, plants, and animals. One of these …