Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes coronavirus
disease 2019 (COVID-19). About 45% of COVID-19 patients experience several symptoms a …

Intracerebral hemorrhage (ICH) is a subtype of stroke with high mortality and disability but
no specific or effective treatment. In the last two decades, much has been learned about the …

Autism spectrum disorder (ASD) is a common neurodevelopmental disorder with onset in
childhood. The mechanisms underlying ASD are unclear. In recent years, the role of …

Mast cell activation plays an important role in stress-mediated disease pathogenesis.
Chronic stress cause or exacerbate aging and age-dependent neurodegenerative diseases …

With the advent of an aging society, the incidence of dementia is increasing, resulting in a
vast burden on society. It is increasingly acknowledged that neuroinflammation is implicated …

Our daily rhythmicity is controlled by a circadian clock with a specific set of genes located in
the suprachiasmatic nucleus in the hypothalamus. Mast cells (MCs) are major effector cells …

Microglia, resident immune cells of the central nervous system (CNS), play a pivotal role in
immune surveillance and maintenance of neuronal health. Mast cells are also important …

The biogenic amine, histamine, has been shown to critically modulate inflammatory
processes as well as the properties of neurons and synapses in the brain, and is also …

Interleukin-33 (IL-33), a member of the IL-1 cytokine family, is involved in various diseases.
IL-33 exerts its effects via its heterodimeric receptor complex, which comprises suppression …

Mast cells (MC) are ubiquitous in the body, and they are critical for not only in allergic
diseases but also in immunity and inflammation, including having potential involvement in …