The detrimental effects of lead poisoning have been well known since ancient times, but
some of the most severe consequences of exposure to this metal have only been described …

Abstract Lead ions (Pb 2+) possess characteristics similar to Ca 2+. Because of this and its
redox capabilities, lead causes different toxic effects. The neurotoxic effects have been well …

Exposure to environmentally relevant levels of lead (Pb2+) during early life produces deficits
in hippocampal synaptic plasticity in the form of long-term potentiation (LTP) and spatial …

There is increasing evidence that toxic metals play a role in diseases of unknown etiology.
Their action is often mediated by membrane proteins, and in particular neurotransmitter …

Historically, amino acids were studied in the context of their importance in protein synthesis.
In the 1950s, the focus of research shifted as amino acids were recognized as putative …

Abstract The Adverse Outcome Pathways (AOPs) are designed to provide mechanistic
understanding of complex biological systems and pathways of toxicity that result in adverse …

Lead (Pb2+) is widely recognized as a neurotoxicant whose mechanisms of action are not
completely established. We have previously demonstrated that Pb2+ can activate the …

Excitotoxic neuronal death has been linked to neurological and neurodegenerative
diseases. Several studies have sought to clarify the involvement of Cl–channels in neuronal …

Objectives Widespread use of heavy metal lead (Pb) for various commercial purposes has
resulted in the environmental contamination caused by this metal. The studies have shown a …

Acid‐sensing ion channels (ASIC) are ligand‐gated cation channels that are highly
expressed in peripheral sensory and central neurons. ASIC are transiently activated by …