The P2X7 receptor channel: recent developments and the use of P2X7 antagonists in models of disease
The P2X7 receptor is a trimeric ATP-gated cation channel found predominantly, but not
exclusively, on immune cells. P2X7 activation results in a number of downstream events …
exclusively, on immune cells. P2X7 activation results in a number of downstream events …
Nuclear ADP-ribosylation reactions in mammalian cells: where are we today and where are we going?
PO Hassa, SS Haenni, M Elser… - … and Molecular Biology …, 2006 - Am Soc Microbiol
Since poly-ADP ribose was discovered over 40 years ago, there has been significant
progress in research into the biology of mono-and poly-ADP-ribosylation reactions. During …
progress in research into the biology of mono-and poly-ADP-ribosylation reactions. During …
NAD-induced T cell death: ADP-ribosylation of cell surface proteins by ART2 activates the cytolytic P2X7 purinoceptor
M Seman, S Adriouch, F Scheuplein, C Krebs… - Immunity, 2003 - cell.com
T cells express a toxin-related ADP-ribosylating ectoenzyme, ART2. Exposure of mature T
cells to NAD, the substrate for ADP-ribosylation, induces cell death. ART2-catalyzed ADP …
cells to NAD, the substrate for ADP-ribosylation, induces cell death. ART2-catalyzed ADP …
CD38: T cell immuno-metabolic modulator
A Kar, S Mehrotra, S Chatterjee - Cells, 2020 - mdpi.com
Activation and subsequent differentiation of T cells following antigenic stimulation are
triggered by highly coordinated signaling events that lead to instilling cells with a discrete …
triggered by highly coordinated signaling events that lead to instilling cells with a discrete …
Cutting edge: a natural P451L mutation in the cytoplasmic domain impairs the function of the mouse P2X7 receptor
S Adriouch, C Dox, V Welge, M Seman… - The Journal of …, 2002 - journals.aai.org
Abstract The P2X7 receptor (P2X 7 R) is an ATP-gated channel that mediates apoptosis of
cells of the immune system. The capacity of P2X 7 R to form large pores depends on its …
cells of the immune system. The capacity of P2X 7 R to form large pores depends on its …
High sensitivity of CD4+ CD25+ regulatory T cells to extracellular metabolites nicotinamide adenine dinucleotide and ATP: a role for P2X7 receptors
F Aswad, H Kawamura, G Dennert - The Journal of Immunology, 2005 - journals.aai.org
Although regulatory lymphocytes play an important role in the immune system, the
regulation of their functions is poorly understood and remains to be elucidated. In this study …
regulation of their functions is poorly understood and remains to be elucidated. In this study …
The good, the bad and the unknown of CD38 in the metabolic microenvironment and immune cell functionality of solid tumors
JM Konen, JJ Fradette, DL Gibbons - Cells, 2019 - mdpi.com
The regulation of the immune microenvironment within solid tumors has received increasing
attention with the development and clinical success of immune checkpoint blockade …
attention with the development and clinical success of immune checkpoint blockade …
The natural history of ADP-ribosyltransferases and the ADP-ribosylation system
Catalysis of NAD+-dependent ADP-ribosylation of proteins, nucleic acids, or small
molecules has evolved in at least three structurally unrelated superfamilies of enzymes …
molecules has evolved in at least three structurally unrelated superfamilies of enzymes …
Extracellular NAD and ATP: Partners in immune cell modulation
F Haag, S Adriouch, A Braß, C Jung, S Möller… - Purinergic …, 2007 - Springer
Extracellular NAD and ATP exert multiple, partially overlapping effects on immune cells.
Catabolism of both nucleotides by extracellular enzymes keeps extracellular concentrations …
Catabolism of both nucleotides by extracellular enzymes keeps extracellular concentrations …
P2X7 on mouse T cells: one channel, many functions
B Rissiek, F Haag, O Boyer, F Koch-Nolte… - Frontiers in …, 2015 - frontiersin.org
The P2X7 receptor is an adenosine triphosphate (ATP)-gated cation channel that is
expressed by several cells of the immune system. P2X7 is best known for its …
expressed by several cells of the immune system. P2X7 is best known for its …