The role of JAK/STAT signaling pathway and its inhibitors in diseases
P Xin, X Xu, C Deng, S Liu, Y Wang, X Zhou… - International …, 2020 - Elsevier
The JAK/STAT signaling pathway is an universally expressed intracellular signal
transduction pathway and involved in many crucial biological processes, including cell …
transduction pathway and involved in many crucial biological processes, including cell …
SOCS proteins in immunity, inflammatory diseases, and immune-related cancer
Cytokine signaling represents one of the cornerstones of the immune system, mediating the
complex responses required to facilitate appropriate immune cell development and function …
complex responses required to facilitate appropriate immune cell development and function …
[HTML][HTML] The regulation of JAKs in cytokine signaling and its breakdown in disease
HM Hammarén, AT Virtanen, J Raivola, O Silvennoinen - Cytokine, 2019 - Elsevier
The JAK–STAT signal transduction pathway is responsible for mediating signals of over fifty
cytokines, growth factors and hormones. Signaling through the JAK–STAT pathway is …
cytokines, growth factors and hormones. Signaling through the JAK–STAT pathway is …
The role of IL-7 and IL-7R in cancer pathophysiology and immunotherapy
C Wang, L Kong, S Kim, S Lee, S Oh, S Jo… - International journal of …, 2022 - mdpi.com
Interleukin-7 (IL-7) is a multipotent cytokine that maintains the homeostasis of the immune
system. IL-7 plays a vital role in T-cell development, proliferation, and differentiation, as well …
system. IL-7 plays a vital role in T-cell development, proliferation, and differentiation, as well …
TLR2 and TLR4 in autoimmune diseases: a comprehensive review
Y Liu, H Yin, M Zhao, Q Lu - Clinical reviews in allergy & immunology, 2014 - Springer
Autoimmune diseases are immune disorders characterized by T cell hyperactivity and B cell
overstimulation leading to overproduction of autoantibodies. Although the pathogenesis of …
overstimulation leading to overproduction of autoantibodies. Although the pathogenesis of …
The IL-6/JAK/STAT3 pathway: potential therapeutic strategies in treating colorectal cancer
SW Wang, YM Sun - International journal of oncology, 2014 - spandidos-publications.com
Among the cytokines linked to inflammation-associated cancer, interleukin (IL)-6 drives
many of the cancer 'hallmarks' through downstream activation of the Janus kinase/signal …
many of the cancer 'hallmarks' through downstream activation of the Janus kinase/signal …
Peptides as therapeutic agents for inflammatory-related diseases
S La Manna, C Di Natale, D Florio… - International journal of …, 2018 - mdpi.com
Inflammation is a physiological mechanism used by organisms to defend themselves
against infection, restoring homeostasis in damaged tissues. It represents the starting point …
against infection, restoring homeostasis in damaged tissues. It represents the starting point …
The role of TLR2 in infectious diseases caused by mycobacteria: from cell biology to therapeutic target
Simple Summary Due to the broad functions of Toll-like receptor 2 (TLR2) in innate
immunity, the drive for the development of TLR2-targeted therapeutic treatments has …
immunity, the drive for the development of TLR2-targeted therapeutic treatments has …
SOCS proteins participate in the regulation of innate immune response caused by viruses
S Huang, K Liu, A Cheng, M Wang, M Cui… - Frontiers in …, 2020 - frontiersin.org
The host immune system has multiple innate immune receptors that can identify, distinguish
and react to viral infections. In innate immune response, the host recognizes pathogen …
and react to viral infections. In innate immune response, the host recognizes pathogen …
The potential therapeutic application of peptides and peptidomimetics in cardiovascular disease
Cardiovascular disease (CVD) remains a leading cause of mortality and morbidity
worldwide. Numerous therapies are currently under investigation to improve pathological …
worldwide. Numerous therapies are currently under investigation to improve pathological …