The human genome encodes 40 voltage-gated K+ channels (KV), which are involved in
diverse physiological processes ranging from repolarization of neuronal and cardiac action …

KCNQ genes encode five Kv7 K+ channel subunits (Kv7. 1–Kv7. 5). Four of these (Kv7. 2–
Kv7. 5) are expressed in the nervous system. Kv7. 2 and Kv7. 3 are the principal molecular …

The intrinsic electrical properties and the synaptic input-output relationships of neurons are
governed by the action of voltage-dependent ion channels. The localization of specific …

Kv7 channels are voltage-gated potassium channels encoded by KCNQ genes that have a
considerable physiological impact in many cell types. This reliance upon Kv7 channels for …

Voltage-gated ion channels are important mediators of physiological functions in the central
nervous system. The cyclic activation of these channels influences neurotransmitter release …

Alcoholism is associated with changes in brain reward and control systems, including the
prefrontal cortex. In prefrontal areas, the orbitofrontal cortex (OFC) has been suggested to …

Activity-dependent persistent changes in neuronal intrinsic excitability and synaptic strength
are widely thought to underlie learning and memory. Voltage-gated KCNQ/Kv7 potassium …

Sudden unexplained death in epilepsy (SUDEP) is the most common cause of premature
mortality in epilepsy and was linked to mutations in ion channels; however, genes within the …

Multiple sclerosis (MS) is a progressive inflammatory demyelinating disease of the CNS.
Increasing evidence suggests that vulnerable neurons in MS exhibit fatal metabolic …

Alcohol use disorders (AUDs) and anxiety disorders (ADs) are often seen concurrently, but
their underlying cellular basis is unclear. For unclear reasons, the lateral habenula (LHb), a …