Knee osteoarthritis: a review of pathogenesis and state-of-the-art non-operative therapeutic considerations
Being the most common musculoskeletal progressive condition, osteoarthritis is an
interesting target for research. It is estimated that the prevalence of knee osteoarthritis (OA) …
interesting target for research. It is estimated that the prevalence of knee osteoarthritis (OA) …
Subchondral bone and osteoarthritis
T Funck-Brentano, M Cohen-Solal - Current opinion in …, 2015 - journals.lww.com
The involvement of bone in osteoarthritis has long been thought to be secondary to cartilage
damage as an adaptation of the joint. Recent clinical studies with MRI have demonstrated …
damage as an adaptation of the joint. Recent clinical studies with MRI have demonstrated …
Non-invasive imaging of cartilage in early osteoarthritis
AJR Palmer, CP Brown, EG McNally… - The bone & joint …, 2013 - boneandjoint.org.uk
Treatment for osteoarthritis (OA) has traditionally focused on joint replacement for end-stage
disease. An increasing number of surgical and pharmaceutical strategies for disease …
disease. An increasing number of surgical and pharmaceutical strategies for disease …
A clinical overview of bone marrow edema
M Manara, M Varenna - Reumatismo, 2014 - reumatismo.org
Bone marrow edema (BME) is a descriptive term which identifies a specific magnetic
resonance imaging (MRI) pattern that can be observed in a number of clinical entities, which …
resonance imaging (MRI) pattern that can be observed in a number of clinical entities, which …
[HTML][HTML] Imaging of cartilage and bone: promises and pitfalls in clinical trials of osteoarthritis
Imaging in clinical trials is used to evaluate subject eligibility, and/or efficacy of intervention,
supporting decision making in drug development by ascertaining treatment effects on joint …
supporting decision making in drug development by ascertaining treatment effects on joint …
Evaluation of bone marrow lesion volume as a knee osteoarthritis biomarker-longitudinal relationships with pain and structural changes: data from the osteoarthritis …
Introduction Bone marrow lesion (BML) size may be an important imaging biomarker for
osteoarthritis-related clinical trials and reducing BML size may be an important therapeutic …
osteoarthritis-related clinical trials and reducing BML size may be an important therapeutic …
Imaging research results from the Osteoarthritis Initiative (OAI): a review and lessons learned 10 years after start of enrolment
The Osteoarthritis Initiative (OAI) is a multicentre, prospective, observational, cohort study of
knee osteoarthritis (OA) that began recruitment in 2004. The OAI provides public access to …
knee osteoarthritis (OA) that began recruitment in 2004. The OAI provides public access to …
Bone marrow lesions detected by specific combination of MRI sequences are associated with severity of osteochondral degeneration
Abstract Background Bone marrow lesions (BMLs) are useful diagnostic and prognostic
markers in knee osteoarthritis (OA), but what they represent at the tissue level remains …
markers in knee osteoarthritis (OA), but what they represent at the tissue level remains …
[HTML][HTML] Bone marrow lesions in knee osteoarthritis: regional differences in tibial subchondral bone microstructure and their association with cartilage degeneration
Objective The aim of this study was to investigate how bone microstructure within bone
marrow lesions (BMLs) relates to the bone and cartilage across the whole human tibial …
marrow lesions (BMLs) relates to the bone and cartilage across the whole human tibial …
[HTML][HTML] The relationship between meniscal pathology and osteoarthritis depends on the type of meniscal damage visible on magnetic resonance images: data from …
Objective To determine the association of different types of meniscal pathology with knee
pain, bone marrow lesion (BML) volume, and end-stage knee osteoarthritis (esKOA). Design …
pain, bone marrow lesion (BML) volume, and end-stage knee osteoarthritis (esKOA). Design …