The trillions of microbes that make up the gut microbiome are an important contributor to
health and disease. With respect to xenobiotics, particularly orally administered compounds …

The microbiome, as a community of microorganisms and their structural elements, genomes,
metabolites/signal molecules, has been shown to play an important role in human health …

Molecular networking (MN) has become a popular data analysis method for untargeted
mass spectrometry (MS)/MS-based metabolomics. Recently, MN has been suggested as a …

Aims Myocardial infarction (MI) is a major cause of death and disability worldwide. Most
metabolomics studies investigating metabolites predicting MI are limited by the participant …

Antibiotics are often used to treat systemic diseases not associated with the oral cavity. This
application of antibiotics may affect the healthy oral microbiota community, as it destroys the …

Molecular networking of non-targeted tandem mass spectrometry data connects structurally
related molecules based on similar fragmentation spectra. Here, we report the Chem ical …

Background Intestinal microbiota has been confirmed to influencing the pharmacokinetic
processes of a variety of oral drugs. However, the pharmacokinetic effects of the gut …

Background The gut microbiome is a diverse system within the gastrointestinal tract
composed of trillions of microorganisms (gut microbiota), along with their genomes …

Introduction Pharmacokinetic variability in disease state is common in clinical practice, but
its underlying mechanism remains unclear. Recently, gut microbiota has been considered to …

Physiologically based pharmacokinetic (PBPK) modeling is a physiologically relevant
approach that integrates drug-specific and system parameters to generate pharmacokinetic …