Agricultural and household applications of pyrethroid insecticides have significantly
increased residual concentrations in living cells and environments. The enhanced …

Mammalian carboxylesterases (CEs) are key enzymes from the serine hydrolase
superfamily. In the human body, two predominant carboxylesterases (CES1 and CES2) …

Background Heart failure (HF) is invariably accompanied by development of cardiac fibrosis,
a form of scarring that increases muscular tissue rigidity and decreases cardiac contractility …

Carboxylesterase (CES) 1 is the most abundant drug-metabolizing enzyme in human livers,
comprising approximately 1% of the entire liver proteome. CES1 is responsible for 80 …

To predict the impact of liver cirrhosis on hepatic drug clearance using physiologically based
pharmacokinetic (PBPK) modeling, we compared the protein abundance of various phase 1 …

Cardiovascular and renal pathologies are frequently associated with an activated renin-
angiotensin-system (RAS) and increased levels of its main effector and vasoconstrictor …

Prodrugs offer a versatile strategy to overcome flaws of viable drug candidates or clinically
approved drugs. However, the strategic importance of prodrugs in the pharmaceutical …

Human carboxylesterases (CESs) are serine hydrolases that are responsible for the phase I
metabolism of an assortment of ester, amide, thioester, carbonate, and carbamate …

The drug-metabolizing enzymes that contribute to the metabolism or bioactivation of a drug
play a crucial role in defining the absorption, distribution, metabolism, and excretion …

Mammalian carboxylesterases (CEs) are important serine hydrolases catalyzing the
hydrolysis of ester-or amide-containing compounds into the corresponding alcohols and …