Pancreatic β-cell electrical activity and insulin secretion: of mice and men
P Rorsman, FM Ashcroft - Physiological reviews, 2018 - journals.physiology.org
The pancreatic β-cell plays a key role in glucose homeostasis by secreting insulin, the only
hormone capable of lowering the blood glucose concentration. Impaired insulin secretion …
hormone capable of lowering the blood glucose concentration. Impaired insulin secretion …
Genetics of obesity: what genetic association studies have taught us about the biology of obesity and its complications
MO Goodarzi - The lancet Diabetes & endocrinology, 2018 - thelancet.com
Genome-wide association studies (GWAS) for BMI, waist-to-hip ratio, and other adiposity
traits have identified more than 300 single-nucleotide polymorphisms (SNPs). Although …
traits have identified more than 300 single-nucleotide polymorphisms (SNPs). Although …
[HTML][HTML] Engineering triangular carbon quantum dots with unprecedented narrow bandwidth emission for multicolored LEDs
F Yuan, T Yuan, L Sui, Z Wang, Z Xi, Y Li, X Li… - Nature …, 2018 - nature.com
Carbon quantum dots (CQDs) have emerged as promising materials for optoelectronic
applications on account of carbon's intrinsic merits of high stability, low cost, and …
applications on account of carbon's intrinsic merits of high stability, low cost, and …
FTO Obesity Variant Circuitry and Adipocyte Browning in Humans
Background Genomewide association studies can be used to identify disease-relevant
genomic regions, but interpretation of the data is challenging. The FTO region harbors the …
genomic regions, but interpretation of the data is challenging. The FTO region harbors the …
Brain insulin resistance at the crossroads of metabolic and cognitive disorders in humans
Ever since the brain was identified as an insulin-sensitive organ, evidence has rapidly
accumulated that insulin action in the brain produces multiple behavioral and metabolic …
accumulated that insulin action in the brain produces multiple behavioral and metabolic …
Recent progress in genetics, epigenetics and metagenomics unveils the pathophysiology of human obesity
In high-, middle-and low-income countries, the rising prevalence of obesity is the underlying
cause of numerous health complications and increased mortality. Being a complex and …
cause of numerous health complications and increased mortality. Being a complex and …
[HTML][HTML] Beyond GWASs: illuminating the dark road from association to function
Genome-wide association studies (GWASs) have enabled the discovery of common genetic
variation contributing to normal and pathological traits and clinical drug responses, but …
variation contributing to normal and pathological traits and clinical drug responses, but …
Obesity-associated variants within FTO form long-range functional connections with IRX3
Genome-wide association studies (GWAS) have reproducibly associated variants within
introns of FTO with increased risk for obesity and type 2 diabetes (T2D),,. Although the …
introns of FTO with increased risk for obesity and type 2 diabetes (T2D),,. Although the …
[HTML][HTML] Dissecting cell identity via network inference and in silico gene perturbation
Cell identity is governed by the complex regulation of gene expression, represented as gene-
regulatory networks. Here we use gene-regulatory networks inferred from single-cell multi …
regulatory networks. Here we use gene-regulatory networks inferred from single-cell multi …
The FTO/miR‐181b‐3p/ARL5B signaling pathway regulates cell migration and invasion in breast cancer
Y Xu, S Ye, N Zhang, S Zheng, H Liu… - Cancer …, 2020 - Wiley Online Library
Abstract Background N6‐methyladenosine (m6A) RNA modification has been demonstrated
to be a significant regulatory process in the progression of various tumors, including breast …
to be a significant regulatory process in the progression of various tumors, including breast …