Obesity is among the most common and costly chronic disorders worldwide. Estimates
suggest that in the United States obesity affects one-third of adults, accounts for up to one …

Ancestral environmental exposures such as toxicants, abnormal nutrition or stress can
promote the epigenetic transgenerational inheritance of disease and phenotypic variation …

Research efforts during the past decades have provided intriguing evidence suggesting that
stressful experiences during pregnancy exert long-term consequences on the future mental …

Objectives Chronic and high consumption of fat constitutes an environmental stress that
leads to metabolic diseases. We hypothesized that high-fat diet (HFD) transgenerationally …

It is known that information that is not contained in the DNA sequence—epigenetic
information—can be inherited from the parent to the offspring. However, many questions …

This review describes new developments in the study of transgenerational epigenetic
inheritance, a component of epigenetics. We start by examining the basic concepts of the …

The burgeoning interest in the field of epigenetics has precipitated the need to develop
approaches to strengthen causal inference when considering the role of epigenetic …

Why do we grow up to look, act, and feel as we do? Through most of the twentieth century,
scientists and laypeople answered this question by referring to two factors alone: our …

Cellular commitment to a specific lineage is controlled by differential silencing of genes,
which in turn depends on epigenetic processes such as DNA methylation and histone …

Choline dietary intake varies such that many people do not achieve adequate intakes. Diet
intake of choline can modulate methylation because, via betaine homocysteine …