[HTML][HTML] Targeting PI3K/AKT signaling pathway in obesity

MS Savova, LV Mihaylova, D Tews, M Wabitsch… - Biomedicine & …, 2023 - Elsevier
Obesity is a disorder with an increasing prevalence, which impairs the life quality of patients
and intensifies societal health care costs. The development of safe and innovative …

FoxO1 signaling as a therapeutic target for type 2 diabetes and obesity

K Benchoula, A Arya, IS Parhar, WE Hwa - European journal of …, 2021 - Elsevier
Glucose production and the consumption of high levels of carbohydrate increase the chance
of insulin resistance, especially in cases of obesity. Therefore, maintaining a balanced …

Insoluble yeast β-glucan attenuates high-fat diet-induced obesity by regulating gut microbiota and its metabolites

X Mo, Y Sun, X Liang, L Li, S Hu, Z Xu, S Liu… - Carbohydrate …, 2022 - Elsevier
Emerging evidence suggests that insoluble dietary fiber prevents obesity by regulating gut
dysbiosis. However, whether insoluble yeast β-glucan (IYG) has an anti-obesity effect is still …

Comparison of the bioactive potential of Roselle (Hibiscus sabdariffa L.) calyx and its by-product: Phenolic characterization by UPLC-QTOF MSE and their anti-obesity …

D Amaya-Cruz, IF Peréz-Ramírez… - Food Research …, 2019 - Elsevier
The aim of the present study was to evaluate extractable (EPP), non-extractable polyphenols
(NEPP) and organic acid in Roselle by-product, as well as its potential health beneficial …

The implication of the crosstalk of Nrf2 with NOXs, and HMGB1 in ethanol-induced gastric ulcer: Potential protective effect is afforded by Raspberry Ketone

AM Badr, NF El-Orabi, RA Ali - PloS one, 2019 - journals.plos.org
Ethanol consumption is one of the common causative agents implicated in gastric ulcer
development. Oxidative stress plays a major role in the induction and development of gastric …

[HTML][HTML] Nobiletin alleviates myocardial ischemia-reperfusion injury via ferroptosis in rats with type-2 diabetes mellitus

Q Huang, L Tian, Y Zhang, Z Qiu, S Lei… - Biomedicine & …, 2023 - Elsevier
Susceptibility to myocardial ischemia-reperfusion (IR) injury in type-2 diabetes (T2DM)
remains disputed, although studies have reported that ferroptosis is associated with …

Effects of dietary red raspberry consumption on pre-diabetes and type 2 diabetes mellitus parameters

SA Derrick, AS Kristo, SK Reaves… - International Journal of …, 2021 - mdpi.com
Type 2 diabetes mellitus (T2DM) is a chronic metabolic condition characterized by glucose
clearance abnormalities and insufficient insulin response. Left uncontrolled, T2DM can …

Hepatoprotective activity of raspberry ketone is mediated via inhibition of the NF-κB/TNF-α/caspase axis and mitochondrial apoptosis in chemically induced acute …

D Fouad, A Badr, HA Attia - Toxicology research, 2019 - academic.oup.com
Raspberry Ketone (RK) is a natural phenolic compound which is marketed nowadays as a
popular weight-reducing remedy, with reported antioxidant and anti-inflammatory activities …

Erica multiflora extract rich in quercetin-3-O-glucoside and kaempferol-3-O-glucoside alleviates high fat and fructose diet-induced fatty liver disease by modulating …

R Khlifi, Z Dhaouefi, IB Toumia, A Lahmar… - The Journal of …, 2020 - Elsevier
The wide morbidity of obesity has heightened interest in providing natural and safe
compounds to maintain optimal health. The present study was designed to determine the …

Raspberry ketone ameliorates nonalcoholic fatty liver disease in rats by activating the AMPK pathway

ME Askar, SI Ali, NN Younis, MA Shaheen… - European Journal of …, 2023 - Elsevier
The current study aimed to investigate the effect of orally administered raspberry ketone
(RK) on ameliorating nonalcoholic fatty liver disease (NAFLD) induced in rats by high-fat …