Nanoplastics (NPLs) are widespread in our environment. However, their impacts on human
health and precise toxicity mechanisms remain poorly understood. Here we studied the …

Papillary thyroid cancer (PTC) remains the most common endocrine malignancy, despite
marked achieves in recent decades, and the mechanisms underlying the pathogenesis and …

Metabolic reprogramming leading to aerobic glycolysis, termed the “Warburg effect,” is a
critical property of cancer cells. However, the precise mechanisms underlying this …

Osteosarcoma (OS) in humans is characterized by alterations in the TP53 gene. In mice,
loss of p53 triggers OS development, for which c‐Myc (Myc) oncogenicity is indispensable …

Background Pancreatic ductal adenocarcinoma (PDAC) is renowned for its formidable and
lethal nature, earning it a notorious reputation among malignant tumors. Due to its …

While γ-glutamylcyclotransferase (GGCT) has been implicated in cancer-cell proliferation,
the role of GGCT enzymatic activity in the regulation of cancer-cell growth remains unclear …

Acute myeloid leukemia (AML) patients with DNA methyltransferase 3A (DNMT3A) mutation
display poor prognosis, and targeted therapy is not available currently. Our previous study …

Background/Aim: γ-Glutamyl cyclotransferase (GGCT) is up-regulated in various cancer
types, including lung cancer. In this study, we evaluated efficacy of gapmer-type antisense …

Abstract γ-Glutamylcyclotransferase (GGCT) is involved in glutathione homeostasis, in which
it catalyzes the reaction that generates 5-oxoproline and free amino acids from γ-glutamyl …

The expression of GGCT (γ‐glutamyl cyclotransferase) is upregulated in various human
cancers. γ‐glutamyl cyclotransferase enzyme activity was originally purified from human red …